Molecular implications of HOX genes targeting multiple signaling pathways in cancer

Homeobox (HOX) genes encode highly conserved homeotic transcription factors that play a crucial role in organogenesis and tissue homeostasis. Their deregulation impacts the function of several regulatory molecules contributing to tumor initiation and progression. A functional bridge exists between a...

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Autores principales: Shenoy, U Sangeetha, Adiga, Divya, Kabekkodu, Shama Prasada, Hunter, Keith D, Radhakrishnan, Raghu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789642/
https://www.ncbi.nlm.nih.gov/pubmed/34617205
http://dx.doi.org/10.1007/s10565-021-09657-2
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author Shenoy, U Sangeetha
Adiga, Divya
Kabekkodu, Shama Prasada
Hunter, Keith D
Radhakrishnan, Raghu
author_facet Shenoy, U Sangeetha
Adiga, Divya
Kabekkodu, Shama Prasada
Hunter, Keith D
Radhakrishnan, Raghu
author_sort Shenoy, U Sangeetha
collection PubMed
description Homeobox (HOX) genes encode highly conserved homeotic transcription factors that play a crucial role in organogenesis and tissue homeostasis. Their deregulation impacts the function of several regulatory molecules contributing to tumor initiation and progression. A functional bridge exists between altered gene expression of individual HOX genes and tumorigenesis. This review focuses on how deregulation in the HOX-associated signaling pathways contributes to the metastatic progression in cancer. We discuss their functional significance, clinical implications and ascertain their role as a diagnostic and prognostic biomarker in the various cancer types. Besides, the mechanism of understanding the theoretical underpinning that affects HOX-mediated therapy resistance in cancers has been outlined. The knowledge gained shall pave the way for newer insights into the treatment of cancer. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-87896422022-02-02 Molecular implications of HOX genes targeting multiple signaling pathways in cancer Shenoy, U Sangeetha Adiga, Divya Kabekkodu, Shama Prasada Hunter, Keith D Radhakrishnan, Raghu Cell Biol Toxicol Review Homeobox (HOX) genes encode highly conserved homeotic transcription factors that play a crucial role in organogenesis and tissue homeostasis. Their deregulation impacts the function of several regulatory molecules contributing to tumor initiation and progression. A functional bridge exists between altered gene expression of individual HOX genes and tumorigenesis. This review focuses on how deregulation in the HOX-associated signaling pathways contributes to the metastatic progression in cancer. We discuss their functional significance, clinical implications and ascertain their role as a diagnostic and prognostic biomarker in the various cancer types. Besides, the mechanism of understanding the theoretical underpinning that affects HOX-mediated therapy resistance in cancers has been outlined. The knowledge gained shall pave the way for newer insights into the treatment of cancer. GRAPHICAL ABSTRACT: [Image: see text] Springer Netherlands 2021-10-06 2022 /pmc/articles/PMC8789642/ /pubmed/34617205 http://dx.doi.org/10.1007/s10565-021-09657-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Shenoy, U Sangeetha
Adiga, Divya
Kabekkodu, Shama Prasada
Hunter, Keith D
Radhakrishnan, Raghu
Molecular implications of HOX genes targeting multiple signaling pathways in cancer
title Molecular implications of HOX genes targeting multiple signaling pathways in cancer
title_full Molecular implications of HOX genes targeting multiple signaling pathways in cancer
title_fullStr Molecular implications of HOX genes targeting multiple signaling pathways in cancer
title_full_unstemmed Molecular implications of HOX genes targeting multiple signaling pathways in cancer
title_short Molecular implications of HOX genes targeting multiple signaling pathways in cancer
title_sort molecular implications of hox genes targeting multiple signaling pathways in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789642/
https://www.ncbi.nlm.nih.gov/pubmed/34617205
http://dx.doi.org/10.1007/s10565-021-09657-2
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