Challenges and Advances in Diagnosis and Treatment of Leptomeningeal Disease (LMD)

Leptomeningeal disease (LMD) is a devastating category of CNS metastasis with a very poor prognosis and limited treatment options. With maximal aggressive therapy, survival times remain short and, without treatment, prognosis is measured in weeks. Both LMD diagnosis and treatment are challenging top...

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Autores principales: Ferguson, Sherise D., Fomchenko, Elena I., Guerrieri, Renato A., Glitza Oliva, Isabella C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789647/
https://www.ncbi.nlm.nih.gov/pubmed/35096602
http://dx.doi.org/10.3389/fonc.2021.800053
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author Ferguson, Sherise D.
Fomchenko, Elena I.
Guerrieri, Renato A.
Glitza Oliva, Isabella C.
author_facet Ferguson, Sherise D.
Fomchenko, Elena I.
Guerrieri, Renato A.
Glitza Oliva, Isabella C.
author_sort Ferguson, Sherise D.
collection PubMed
description Leptomeningeal disease (LMD) is a devastating category of CNS metastasis with a very poor prognosis and limited treatment options. With maximal aggressive therapy, survival times remain short and, without treatment, prognosis is measured in weeks. Both LMD diagnosis and treatment are challenging topics within neuro-oncology. In this review, we discuss the advances in LMD diagnosis with a focus on the role of circulating tumor DNA (ctDNA) and discuss the role of targeted and immunotherapy in LMD treatment.
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spelling pubmed-87896472022-01-27 Challenges and Advances in Diagnosis and Treatment of Leptomeningeal Disease (LMD) Ferguson, Sherise D. Fomchenko, Elena I. Guerrieri, Renato A. Glitza Oliva, Isabella C. Front Oncol Oncology Leptomeningeal disease (LMD) is a devastating category of CNS metastasis with a very poor prognosis and limited treatment options. With maximal aggressive therapy, survival times remain short and, without treatment, prognosis is measured in weeks. Both LMD diagnosis and treatment are challenging topics within neuro-oncology. In this review, we discuss the advances in LMD diagnosis with a focus on the role of circulating tumor DNA (ctDNA) and discuss the role of targeted and immunotherapy in LMD treatment. Frontiers Media S.A. 2022-01-12 /pmc/articles/PMC8789647/ /pubmed/35096602 http://dx.doi.org/10.3389/fonc.2021.800053 Text en Copyright © 2022 Ferguson, Fomchenko, Guerrieri and Glitza Oliva https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Ferguson, Sherise D.
Fomchenko, Elena I.
Guerrieri, Renato A.
Glitza Oliva, Isabella C.
Challenges and Advances in Diagnosis and Treatment of Leptomeningeal Disease (LMD)
title Challenges and Advances in Diagnosis and Treatment of Leptomeningeal Disease (LMD)
title_full Challenges and Advances in Diagnosis and Treatment of Leptomeningeal Disease (LMD)
title_fullStr Challenges and Advances in Diagnosis and Treatment of Leptomeningeal Disease (LMD)
title_full_unstemmed Challenges and Advances in Diagnosis and Treatment of Leptomeningeal Disease (LMD)
title_short Challenges and Advances in Diagnosis and Treatment of Leptomeningeal Disease (LMD)
title_sort challenges and advances in diagnosis and treatment of leptomeningeal disease (lmd)
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789647/
https://www.ncbi.nlm.nih.gov/pubmed/35096602
http://dx.doi.org/10.3389/fonc.2021.800053
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