Intra-islet glucagon confers β-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon

We report that intra-islet glucagon secreted from α-cells signals through β-cell glucagon and GLP-1 receptors (GcgR and GLP-1R), thereby conferring to rat islets their competence to exhibit first-phase glucose-stimulated insulin secretion (GSIS). Thus, in islets not treated with exogenous glucagon o...

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Detalles Bibliográficos
Autores principales: Cabrera, Over, Ficorilli, James, Shaw, Janice, Echeverri, Felipe, Schwede, Frank, Chepurny, Oleg G., Leech, Colin A., Holz, George G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789663/
https://www.ncbi.nlm.nih.gov/pubmed/34896391
http://dx.doi.org/10.1016/j.jbc.2021.101484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789663/
https://www.ncbi.nlm.nih.gov/pubmed/34896391
http://dx.doi.org/10.1016/j.jbc.2021.101484

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