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Zebrafish as a Useful Tool in the Research of Natural Products With Potential Anxiolytic Effects

Zebrafish (Danio rerio) is a popular and valuable species used in many different biomedical research areas. The complex behavior that fish exhibit in response to different stimuli allows researchers to explore the biological and pharmacological basis of affective and mood disorders. In this sense, a...

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Autores principales: Cueto-Escobedo, Jonathan, German-Ponciano, León Jesús, Guillén-Ruiz, Gabriel, Soria-Fregozo, Cesar, Herrera-Huerta, Emma Virginia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789748/
https://www.ncbi.nlm.nih.gov/pubmed/35095438
http://dx.doi.org/10.3389/fnbeh.2021.795285
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author Cueto-Escobedo, Jonathan
German-Ponciano, León Jesús
Guillén-Ruiz, Gabriel
Soria-Fregozo, Cesar
Herrera-Huerta, Emma Virginia
author_facet Cueto-Escobedo, Jonathan
German-Ponciano, León Jesús
Guillén-Ruiz, Gabriel
Soria-Fregozo, Cesar
Herrera-Huerta, Emma Virginia
author_sort Cueto-Escobedo, Jonathan
collection PubMed
description Zebrafish (Danio rerio) is a popular and valuable species used in many different biomedical research areas. The complex behavior that fish exhibit in response to different stimuli allows researchers to explore the biological and pharmacological basis of affective and mood disorders. In this sense, anxiety is commonly studied in preclinical research with animal models in rodents. During the last decade, those models have been successfully adapted to zebrafish. Stressful stimuli, such as novel environments, chemical substances, light conditions, and predator images, can trigger defensive behaviors considered indicators of an anxiety-like state. In the first stage, models were adapted and validated with different stressors and anxiolytic drugs with promising results and are now successfully used to generate scientific knowledge. In that sense, zebrafish allows several routes of administration and other methodological advantages to explore the anxiolytic effects of natural products in behavioral tests as novel tank, light-dark chamber, and black/white maze, among others. The present work will review the main findings on preclinical research using adult zebrafish to explore anxiolytics effects of natural products as plant secondary metabolites such as flavonoids, alkaloids and terpenes or standardized extracts of plants, among others. Scientific literature confirms the utility of zebrafish tests to explore anxiety-like states and anxiolytic-like effects of plant secondary metabolites, which represent a useful and ethical tool in the first stages of behavioral.
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spelling pubmed-87897482022-01-27 Zebrafish as a Useful Tool in the Research of Natural Products With Potential Anxiolytic Effects Cueto-Escobedo, Jonathan German-Ponciano, León Jesús Guillén-Ruiz, Gabriel Soria-Fregozo, Cesar Herrera-Huerta, Emma Virginia Front Behav Neurosci Behavioral Neuroscience Zebrafish (Danio rerio) is a popular and valuable species used in many different biomedical research areas. The complex behavior that fish exhibit in response to different stimuli allows researchers to explore the biological and pharmacological basis of affective and mood disorders. In this sense, anxiety is commonly studied in preclinical research with animal models in rodents. During the last decade, those models have been successfully adapted to zebrafish. Stressful stimuli, such as novel environments, chemical substances, light conditions, and predator images, can trigger defensive behaviors considered indicators of an anxiety-like state. In the first stage, models were adapted and validated with different stressors and anxiolytic drugs with promising results and are now successfully used to generate scientific knowledge. In that sense, zebrafish allows several routes of administration and other methodological advantages to explore the anxiolytic effects of natural products in behavioral tests as novel tank, light-dark chamber, and black/white maze, among others. The present work will review the main findings on preclinical research using adult zebrafish to explore anxiolytics effects of natural products as plant secondary metabolites such as flavonoids, alkaloids and terpenes or standardized extracts of plants, among others. Scientific literature confirms the utility of zebrafish tests to explore anxiety-like states and anxiolytic-like effects of plant secondary metabolites, which represent a useful and ethical tool in the first stages of behavioral. Frontiers Media S.A. 2022-01-12 /pmc/articles/PMC8789748/ /pubmed/35095438 http://dx.doi.org/10.3389/fnbeh.2021.795285 Text en Copyright © 2022 Cueto-Escobedo, German-Ponciano, Guillén-Ruiz, Soria-Fregozo and Herrera-Huerta. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Behavioral Neuroscience
Cueto-Escobedo, Jonathan
German-Ponciano, León Jesús
Guillén-Ruiz, Gabriel
Soria-Fregozo, Cesar
Herrera-Huerta, Emma Virginia
Zebrafish as a Useful Tool in the Research of Natural Products With Potential Anxiolytic Effects
title Zebrafish as a Useful Tool in the Research of Natural Products With Potential Anxiolytic Effects
title_full Zebrafish as a Useful Tool in the Research of Natural Products With Potential Anxiolytic Effects
title_fullStr Zebrafish as a Useful Tool in the Research of Natural Products With Potential Anxiolytic Effects
title_full_unstemmed Zebrafish as a Useful Tool in the Research of Natural Products With Potential Anxiolytic Effects
title_short Zebrafish as a Useful Tool in the Research of Natural Products With Potential Anxiolytic Effects
title_sort zebrafish as a useful tool in the research of natural products with potential anxiolytic effects
topic Behavioral Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789748/
https://www.ncbi.nlm.nih.gov/pubmed/35095438
http://dx.doi.org/10.3389/fnbeh.2021.795285
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