Cargando…

A genome-wide association study of serum proteins reveals shared loci with common diseases

With the growing number of genetic association studies, the genotype-phenotype atlas has become increasingly more complex, yet the functional consequences of most disease associated alleles is not understood. The measurement of protein level variation in solid tissues and biofluids integrated with g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gudjonsson, Alexander, Gudmundsdottir, Valborg, Axelsson, Gisli T., Gudmundsson, Elias F., Jonsson, Brynjolfur G., Launer, Lenore J., Lamb, John R., Jennings, Lori L., Aspelund, Thor, Emilsson, Valur, Gudnason, Vilmundur
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789779/ https://www.ncbi.nlm.nih.gov/pubmed/35078996 http://dx.doi.org/10.1038/s41467-021-27850-z

Ejemplares similares

Antihypertensive medication uses and serum ACE2 levels: ACEIs/ARBs treatment does not raise serum levels of ACE2
por: Emilsson, Valur, et al.
Publicado: (2020)

ACE2 levels are altered in comorbidities linked to severe outcome in COVID-19
por: Emilsson, Valur, et al.
Publicado: (2020)

Serum levels of ACE2 are higher in patients with obesity and diabetes
por: Emilsson, Valur, et al.
Publicado: (2020)

Coding and regulatory variants are associated with serum protein levels and disease
por: Emilsson, Valur, et al.
Publicado: (2022)

Circulating Protein Signatures and Causal Candidates for Type 2 Diabetes
por: Gudmundsdottir, Valborg, et al.
Publicado: (2020)

A proteomic analysis of atrial fibrillation in a prospective longitudinal cohort (AGES-Reykjavik study)
por: Jonmundsson, Thorarinn, et al.
Publicado: (2023)

A proteogenomic signature of age-related macular degeneration in blood
por: Emilsson, Valur, et al.
Publicado: (2022)

Serum proteomics reveals APOE dependent and independent protein signatures in Alzheimer’s disease
por: Frick, Elisabet A., et al.
Publicado: (2023)

Hyperuricemia is associated with intermittent hand joint pain in a cross sectional study of elderly females: The AGES-Reykjavik Study
por: Jonsson, Helgi, et al.
Publicado: (2019)

Interstitial lung abnormalities and physical function
por: Axelsson, Gisli Thor, et al.
Publicado: (2018)

Migraine with aura and risk of cardiovascular and all cause mortality in men and women: prospective cohort study
por: Gudmundsson, Larus S, et al.
Publicado: (2010)

Proteomic Analysis Identifies Circulating Proteins Associated With Plasma Amyloid-β and Incident Dementia
por: Tin, Adrienne, et al.
Publicado: (2022)

Incidence and prevalence of total joint replacements due to osteoarthritis in the elderly: risk factors and factors associated with late life prevalence in the AGES-Reykjavik Study
por: Jonsson, Helgi, et al.
Publicado: (2016)

Heterogeneity in White Blood Cells Has Potential to Confound DNA Methylation Measurements
por: Adalsteinsson, Bjorn T., et al.
Publicado: (2012)

Hand Osteoarthritis Severity is Associated with Total Knee Joint Replacements Independently of BMI. The Ages-Reykjavik Study
por: Jonsson, Helgi, et al.
Publicado: (2011)

Type 3 finger length pattern is associated with total knee replacements due to osteoarthritis but not with hip replacements or hand osteoarthritis in the elderly: The AGES-Reykjavik study
por: Sigurjonsdottir, Kristin, et al.
Publicado: (2013)

Effects of statin medication on mortality risk associated with type 2 diabetes in older persons: the population-based AGES-Reykjavik Study
por: Olafsdottir, Elin, et al.
Publicado: (2011)

Similar decline in mortality rate of older persons with and without type 2 diabetes between 1993 and 2004 the Icelandic population-based Reykjavik and AGES-Reykjavik cohort studies
por: Olafsdottir, Elin, et al.
Publicado: (2013)

The use of digital photographs for the diagnosis of hand osteoarthritis: the AGES-Reykjavik study
por: Jonsson, Helgi, et al.
Publicado: (2012)

Fat Distribution and Mortality: The AGES-Reykjavik Study
por: Koster, Annemarie, et al.
Publicado: (2015)

Interstitial lung abnormalities – current knowledge and future directions
por: Axelsson, Gisli Thor, et al.
Publicado: (2021)

Feasibility of Using Pseudo-Continuous Arterial Spin Labeling Perfusion in a Geriatric Population at 1.5 Tesla
por: Sigurdsson, Sigurdur, et al.
Publicado: (2015)

Social Participation and the Risk for Developing Mild Cognitive Impairment and Dementia Among Older Adults
por: Eymundsdottir, Hrafnhildur, et al.
Publicado: (2021)

Longitudinal Association Between Education and Disability in Older Adults Living in Iceland
por: Chang, Milan, et al.
Publicado: (2020)

Body weight changes and longitudinal associations with cognitive decline among community‐dwelling older adults
por: Eymundsdottir, Hrafnhildur, et al.
Publicado: (2021)

Population distribution of traditional and the emerging cardiovascular risk factors carotid plaque and IMT: the REFINE-Reykjavik study with comparison with the Tromsø study
por: Thorsson, Bolli, et al.
Publicado: (2018)

Serum DHEA and Testosterone Levels Associate Inversely With Coronary Artery Calcification in Elderly Men
por: Ohlsson, Claes, et al.
Publicado: (2023)

Community awareness of stroke in Accra, Ghana
por: Donkor, Eric S, et al.
Publicado: (2014)

Proteomic Network Analysis of Alzheimer’s Disease Cerebrospinal Fluid Reveals Alterations Associated with APOE ε4 Genotype and Atomoxetine Treatment
por: Dammer, Eric B., et al.
Publicado: (2023)

Dietary habits in adolescence and midlife and risk of breast cancer in older women
por: Haraldsdottir, Alfheidur, et al.
Publicado: (2018)

Correction: Dietary habits in adolescence and midlife and risk of breast cancer in older women
por: Haraldsdottir, Alfheidur, et al.
Publicado: (2018)

Socioeconomic factors from midlife predict mobility limitation and depressed mood three decades later; Findings from the AGES-Reykjavik Study
por: Groffen, Daniëlle AI, et al.
Publicado: (2013)

Prevalence and prognosis of non-ischemic patterns of late gadolinium enhancement in older adults by cardiovascular MR in the ICELAND-MI study
por: Shanbhag, Sujata M, et al.
Publicado: (2016)

Respiratory function and CT abnormalities among survivors of COVID-19 pneumonia: a nationwide follow-up study
por: Axelsson, Gisli Thor, et al.
Publicado: (2022)

Effect of Birth Year on Birth Weight and Obesity in Adulthood: Comparison between Subjects Born Prior to and during the Great Depression in Iceland
por: Imai, Cindy Mari, et al.
Publicado: (2012)

Chronic kidney disease and risk of major cardiovascular disease and non-vascular mortality: prospective population based cohort study
por: Di Angelantonio, Emanuele, et al.
Publicado: (2010)

Population Assessment of Future Trajectories in Coronary Heart Disease Mortality
por: Thorolfsdottir, Rosa Björk, et al.
Publicado: (2014)

Metabolic and proteomic signatures of type 2 diabetes subtypes in an Arab population
por: Zaghlool, Shaza B., et al.
Publicado: (2022)

Longitudinal and Circumferential Strain of the Proximal Aorta
por: Bell, Vanessa, et al.
Publicado: (2014)

Persistent Chlamydia Pneumoniae serology is related to decline in lung function in women but not in men. Effect of persistent Chlamydia pneumoniae infection on lung function
por: Gislason, Thorarinn, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_6tnsofhmvbqtpge87assl8oj3e