Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia

A gain-of-function mutation in the fibroblast growth factor receptor 3 gene (FGFR3) results in achondroplasia (ACH), the most frequent form of dwarfism. Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways. Identification of new and relevant co...

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Detalles Bibliográficos
Autores principales: Martin, Ludovic, Kaci, Nabil, Benoist-Lasselin, Catherine, Mondoloni, Marine, Decaudaveine, Suzanne, Estibals, Valentin, Cornille, Maxence, Loisay, Léa, Flipo, Justine, Demuynck, Benoît, de la Luz Cádiz-Gurrea, Maria, Barbault, Florent, Fernández-Arroyo, Salvador, Schibler, Laurent, Segura-Carretero, Antonio, Dambroise, Emilie, Legeai-Mallet, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789790/
https://www.ncbi.nlm.nih.gov/pubmed/35078974
http://dx.doi.org/10.1038/s41413-021-00177-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789790/
https://www.ncbi.nlm.nih.gov/pubmed/35078974
http://dx.doi.org/10.1038/s41413-021-00177-7

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