A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host

The Kaposi’s sarcoma associated herpesvirus protein ORF45 binds the extracellular signal-regulated kinase (ERK) and the p90 Ribosomal S6 kinase (RSK). ORF45 was shown to be a kinase activator in cells but a kinase inhibitor in vitro, and its effects on the ERK-RSK complex are unknown. Here, we demon...

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Detalles Bibliográficos
Autores principales: Alexa, Anita, Sok, Péter, Gross, Fridolin, Albert, Krisztián, Kobori, Evan, Póti, Ádám L., Gógl, Gergő, Bento, Isabel, Kuang, Ersheng, Taylor, Susan S., Zhu, Fanxiu, Ciliberto, Andrea, Reményi, Attila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789800/
https://www.ncbi.nlm.nih.gov/pubmed/35078976
http://dx.doi.org/10.1038/s41467-022-28109-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789800/
https://www.ncbi.nlm.nih.gov/pubmed/35078976
http://dx.doi.org/10.1038/s41467-022-28109-x

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