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Cold shock induces a terminal investment reproductive response in C. elegans

Challenges from environmental stressors have a profound impact on many life-history traits of an organism, including reproductive strategy. Examples across multiple taxa have demonstrated that maternal reproductive investment resulting from stress can improve offspring survival; a form of matricidal...

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Autores principales: Gulyas, Leah, Powell, Jennifer R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789813/
https://www.ncbi.nlm.nih.gov/pubmed/35079060
http://dx.doi.org/10.1038/s41598-022-05340-6
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author Gulyas, Leah
Powell, Jennifer R.
author_facet Gulyas, Leah
Powell, Jennifer R.
author_sort Gulyas, Leah
collection PubMed
description Challenges from environmental stressors have a profound impact on many life-history traits of an organism, including reproductive strategy. Examples across multiple taxa have demonstrated that maternal reproductive investment resulting from stress can improve offspring survival; a form of matricidal provisioning when death appears imminent is known as terminal investment. Here we report a reproductive response in the nematode Caenorhabditis elegans upon exposure to acute cold shock at 2 °C, whereby vitellogenic lipid movement from the soma to the germline appears to be massively upregulated at the expense of parental survival. This response is dependent on functional TAX-2; TAX-4 cGMP-gated channels that are part of canonical thermosensory mechanisms in worms and can be prevented in the presence of activated SKN-1/Nrf2, the master stress regulator. Increased maternal provisioning promotes improved embryonic cold shock survival, which is notably suppressed in animals with impaired vitellogenesis. These findings suggest that cold shock in C. elegans triggers terminal investment to promote progeny fitness at the expense of parental survival and may serve as a tractable model for future studies of stress-induced progeny plasticity.
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spelling pubmed-87898132022-01-27 Cold shock induces a terminal investment reproductive response in C. elegans Gulyas, Leah Powell, Jennifer R. Sci Rep Article Challenges from environmental stressors have a profound impact on many life-history traits of an organism, including reproductive strategy. Examples across multiple taxa have demonstrated that maternal reproductive investment resulting from stress can improve offspring survival; a form of matricidal provisioning when death appears imminent is known as terminal investment. Here we report a reproductive response in the nematode Caenorhabditis elegans upon exposure to acute cold shock at 2 °C, whereby vitellogenic lipid movement from the soma to the germline appears to be massively upregulated at the expense of parental survival. This response is dependent on functional TAX-2; TAX-4 cGMP-gated channels that are part of canonical thermosensory mechanisms in worms and can be prevented in the presence of activated SKN-1/Nrf2, the master stress regulator. Increased maternal provisioning promotes improved embryonic cold shock survival, which is notably suppressed in animals with impaired vitellogenesis. These findings suggest that cold shock in C. elegans triggers terminal investment to promote progeny fitness at the expense of parental survival and may serve as a tractable model for future studies of stress-induced progeny plasticity. Nature Publishing Group UK 2022-01-25 /pmc/articles/PMC8789813/ /pubmed/35079060 http://dx.doi.org/10.1038/s41598-022-05340-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Gulyas, Leah
Powell, Jennifer R.
Cold shock induces a terminal investment reproductive response in C. elegans
title Cold shock induces a terminal investment reproductive response in C. elegans
title_full Cold shock induces a terminal investment reproductive response in C. elegans
title_fullStr Cold shock induces a terminal investment reproductive response in C. elegans
title_full_unstemmed Cold shock induces a terminal investment reproductive response in C. elegans
title_short Cold shock induces a terminal investment reproductive response in C. elegans
title_sort cold shock induces a terminal investment reproductive response in c. elegans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789813/
https://www.ncbi.nlm.nih.gov/pubmed/35079060
http://dx.doi.org/10.1038/s41598-022-05340-6
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