Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity

The specificity of CRISPR/Cas9 genome editing is largely determined by the sequences of guide RNA (gRNA) and the targeted DNA, yet the sequence-dependent rules underlying off-target effects are not fully understood. To systematically explore the sequence determinants governing CRISPR/Cas9 specificit...

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Detalles Bibliográficos
Autores principales: Fu, Rongjie, He, Wei, Dou, Jinzhuang, Villarreal, Oscar D., Bedford, Ella, Wang, Helen, Hou, Connie, Zhang, Liang, Wang, Yalong, Ma, Dacheng, Chen, Yiwen, Gao, Xue, Depken, Martin, Xu, Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789861/
https://www.ncbi.nlm.nih.gov/pubmed/35078987
http://dx.doi.org/10.1038/s41467-022-28028-x

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