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Scalp HFO rates decrease after successful epilepsy surgery and are not impacted by the skull defect resulting from craniotomy

Epilepsy surgery can achieve seizure freedom in selected pediatric candidates, but reliable postsurgical predictors of seizure freedom are missing. High frequency oscillations (HFO) in scalp EEG are a new and promising biomarker of treatment response. However, it is unclear if the skull defect resul...

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Autores principales: Cserpan, Dorottya, Gennari, Antonio, Gaito, Luca, Lo Biundo, Santo Pietro, Tuura, Ruth, Sarnthein, Johannes, Ramantani, Georgia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789862/
https://www.ncbi.nlm.nih.gov/pubmed/35079091
http://dx.doi.org/10.1038/s41598-022-05373-x
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author Cserpan, Dorottya
Gennari, Antonio
Gaito, Luca
Lo Biundo, Santo Pietro
Tuura, Ruth
Sarnthein, Johannes
Ramantani, Georgia
author_facet Cserpan, Dorottya
Gennari, Antonio
Gaito, Luca
Lo Biundo, Santo Pietro
Tuura, Ruth
Sarnthein, Johannes
Ramantani, Georgia
author_sort Cserpan, Dorottya
collection PubMed
description Epilepsy surgery can achieve seizure freedom in selected pediatric candidates, but reliable postsurgical predictors of seizure freedom are missing. High frequency oscillations (HFO) in scalp EEG are a new and promising biomarker of treatment response. However, it is unclear if the skull defect resulting from craniotomy interferes with HFO detection in postsurgical recordings. We considered 14 children with focal lesional epilepsy who underwent presurgical evaluation, epilepsy surgery, and postsurgical follow-up of ≥ 1 year. We identified the nearest EEG electrodes to the skull defect in the postsurgical MRI. We applied a previously validated automated HFO detector to determine HFO rates in presurgical and postsurgical EEG. Overall, HFO rates showed a positive correlation with seizure frequency (p < 0.001). HFO rates in channels over the HFO area decreased following successful epilepsy surgery, irrespective of their proximity to the skull defect (p = 0.005). HFO rates in channels outside the HFO area but near the skull defect showed no increase following surgery (p = 0.091) and did not differ from their contralateral channels (p = 0.726). Our observations show that the skull defect does not interfere with postsurgical HFO detection. This supports the notion that scalp HFO can predict postsurgical seizure freedom and thus guide therapy management in focal lesional epilepsy.
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spelling pubmed-87898622022-01-27 Scalp HFO rates decrease after successful epilepsy surgery and are not impacted by the skull defect resulting from craniotomy Cserpan, Dorottya Gennari, Antonio Gaito, Luca Lo Biundo, Santo Pietro Tuura, Ruth Sarnthein, Johannes Ramantani, Georgia Sci Rep Article Epilepsy surgery can achieve seizure freedom in selected pediatric candidates, but reliable postsurgical predictors of seizure freedom are missing. High frequency oscillations (HFO) in scalp EEG are a new and promising biomarker of treatment response. However, it is unclear if the skull defect resulting from craniotomy interferes with HFO detection in postsurgical recordings. We considered 14 children with focal lesional epilepsy who underwent presurgical evaluation, epilepsy surgery, and postsurgical follow-up of ≥ 1 year. We identified the nearest EEG electrodes to the skull defect in the postsurgical MRI. We applied a previously validated automated HFO detector to determine HFO rates in presurgical and postsurgical EEG. Overall, HFO rates showed a positive correlation with seizure frequency (p < 0.001). HFO rates in channels over the HFO area decreased following successful epilepsy surgery, irrespective of their proximity to the skull defect (p = 0.005). HFO rates in channels outside the HFO area but near the skull defect showed no increase following surgery (p = 0.091) and did not differ from their contralateral channels (p = 0.726). Our observations show that the skull defect does not interfere with postsurgical HFO detection. This supports the notion that scalp HFO can predict postsurgical seizure freedom and thus guide therapy management in focal lesional epilepsy. Nature Publishing Group UK 2022-01-25 /pmc/articles/PMC8789862/ /pubmed/35079091 http://dx.doi.org/10.1038/s41598-022-05373-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Cserpan, Dorottya
Gennari, Antonio
Gaito, Luca
Lo Biundo, Santo Pietro
Tuura, Ruth
Sarnthein, Johannes
Ramantani, Georgia
Scalp HFO rates decrease after successful epilepsy surgery and are not impacted by the skull defect resulting from craniotomy
title Scalp HFO rates decrease after successful epilepsy surgery and are not impacted by the skull defect resulting from craniotomy
title_full Scalp HFO rates decrease after successful epilepsy surgery and are not impacted by the skull defect resulting from craniotomy
title_fullStr Scalp HFO rates decrease after successful epilepsy surgery and are not impacted by the skull defect resulting from craniotomy
title_full_unstemmed Scalp HFO rates decrease after successful epilepsy surgery and are not impacted by the skull defect resulting from craniotomy
title_short Scalp HFO rates decrease after successful epilepsy surgery and are not impacted by the skull defect resulting from craniotomy
title_sort scalp hfo rates decrease after successful epilepsy surgery and are not impacted by the skull defect resulting from craniotomy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8789862/
https://www.ncbi.nlm.nih.gov/pubmed/35079091
http://dx.doi.org/10.1038/s41598-022-05373-x
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