Successful Imatinib Treatment for Systemic Mastocytosis Associated With Myelodysplastic/Myeloproliferative Neoplasm: Report of a Case and Literature Review

Systemic mastocytosis (SM) is a heterogeneous disease characterized by the expansion of mast cells in one or more tissues, frequently characterized by the presence of KITD816V mutation. The updated World Health Organization (WHO) classification of myeloid neoplasms recognizes SM with an associated h...

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Detalles Bibliográficos
Autores principales: Barozzi, Enrico, Bucelli, Cristina, Grifoni, Federica Irene, Gianelli, Umberto, Iurlo, Alessandra, Cattaneo, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790034/
https://www.ncbi.nlm.nih.gov/pubmed/35096623
http://dx.doi.org/10.3389/fonc.2021.819097
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author Barozzi, Enrico
Bucelli, Cristina
Grifoni, Federica Irene
Gianelli, Umberto
Iurlo, Alessandra
Cattaneo, Daniele
author_facet Barozzi, Enrico
Bucelli, Cristina
Grifoni, Federica Irene
Gianelli, Umberto
Iurlo, Alessandra
Cattaneo, Daniele
author_sort Barozzi, Enrico
collection PubMed
description Systemic mastocytosis (SM) is a heterogeneous disease characterized by the expansion of mast cells in one or more tissues, frequently characterized by the presence of KITD816V mutation. The updated World Health Organization (WHO) classification of myeloid neoplasms recognizes SM with an associated hematological neoplasm (SM-AHN) as a new subtype among the others, which is depicted by the coexistence of SM with another hematological clonal disease. Prognosis is very different among SM patients, while its treatment, although highly personalized, is still challenging. Here we report a case of KITD816V-unmutated SM associated with MDS/MPN successfully treated with imatinib.
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spelling pubmed-87900342022-01-27 Successful Imatinib Treatment for Systemic Mastocytosis Associated With Myelodysplastic/Myeloproliferative Neoplasm: Report of a Case and Literature Review Barozzi, Enrico Bucelli, Cristina Grifoni, Federica Irene Gianelli, Umberto Iurlo, Alessandra Cattaneo, Daniele Front Oncol Oncology Systemic mastocytosis (SM) is a heterogeneous disease characterized by the expansion of mast cells in one or more tissues, frequently characterized by the presence of KITD816V mutation. The updated World Health Organization (WHO) classification of myeloid neoplasms recognizes SM with an associated hematological neoplasm (SM-AHN) as a new subtype among the others, which is depicted by the coexistence of SM with another hematological clonal disease. Prognosis is very different among SM patients, while its treatment, although highly personalized, is still challenging. Here we report a case of KITD816V-unmutated SM associated with MDS/MPN successfully treated with imatinib. Frontiers Media S.A. 2022-01-12 /pmc/articles/PMC8790034/ /pubmed/35096623 http://dx.doi.org/10.3389/fonc.2021.819097 Text en Copyright © 2022 Barozzi, Bucelli, Grifoni, Gianelli, Iurlo and Cattaneo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Barozzi, Enrico
Bucelli, Cristina
Grifoni, Federica Irene
Gianelli, Umberto
Iurlo, Alessandra
Cattaneo, Daniele
Successful Imatinib Treatment for Systemic Mastocytosis Associated With Myelodysplastic/Myeloproliferative Neoplasm: Report of a Case and Literature Review
title Successful Imatinib Treatment for Systemic Mastocytosis Associated With Myelodysplastic/Myeloproliferative Neoplasm: Report of a Case and Literature Review
title_full Successful Imatinib Treatment for Systemic Mastocytosis Associated With Myelodysplastic/Myeloproliferative Neoplasm: Report of a Case and Literature Review
title_fullStr Successful Imatinib Treatment for Systemic Mastocytosis Associated With Myelodysplastic/Myeloproliferative Neoplasm: Report of a Case and Literature Review
title_full_unstemmed Successful Imatinib Treatment for Systemic Mastocytosis Associated With Myelodysplastic/Myeloproliferative Neoplasm: Report of a Case and Literature Review
title_short Successful Imatinib Treatment for Systemic Mastocytosis Associated With Myelodysplastic/Myeloproliferative Neoplasm: Report of a Case and Literature Review
title_sort successful imatinib treatment for systemic mastocytosis associated with myelodysplastic/myeloproliferative neoplasm: report of a case and literature review
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790034/
https://www.ncbi.nlm.nih.gov/pubmed/35096623
http://dx.doi.org/10.3389/fonc.2021.819097
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