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KIR-HLA Functional Repertoire Influences Trastuzumab Efficiency in Patients With HER2-Positive Breast Cancer

Trastuzumab induced a high rate of pathological Complete Response (pCR) in patients affected by locally advanced HER2-positive Breast Cancer (HER2-BC), by exploiting immune-mediated mechanisms as Antibody-Dependent Cell Cytotoxicity (ADCC) involving Natural Killer (NK) cells. Host’s immune genetics...

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Detalles Bibliográficos
Autores principales:	Muraro, Elena, De Zorzi, Mariangela, Miolo, Gianmaria, Lombardi, Davide, Scalone, Simona, Spazzapan, Simon, Massarut, Samuele, Perin, Tiziana, Dolcetti, Riccardo, Steffan, Agostino, De Re, Valli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790064/ https://www.ncbi.nlm.nih.gov/pubmed/35095867 http://dx.doi.org/10.3389/fimmu.2021.791958

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