Cargando…

Prognostic Factor Analysis and Nomogram Construction of Primary Retroperitoneal Liposarcoma: A Review of 10 Years of Treatment Experience in a Single Asian Cohort of 211 Cases

OBJECTIVE: This study intended to retrospectively analyze the data of patients with primary retroperitoneal liposarcoma in a single Asian large-volume sarcoma center and to establish nomograms focused on PRLPS for predicting progression-free survival (PFS) and overall survival (OS). METHODS: A total...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhuang, Aobo, Zhuang, Aojia, Wu, Qian, Lu, Weiqi, Tong, Hanxing, Zhang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790090/
https://www.ncbi.nlm.nih.gov/pubmed/35096578
http://dx.doi.org/10.3389/fonc.2021.777647
_version_ 1784639916151406592
author Zhuang, Aobo
Zhuang, Aojia
Wu, Qian
Lu, Weiqi
Tong, Hanxing
Zhang, Yong
author_facet Zhuang, Aobo
Zhuang, Aojia
Wu, Qian
Lu, Weiqi
Tong, Hanxing
Zhang, Yong
author_sort Zhuang, Aobo
collection PubMed
description OBJECTIVE: This study intended to retrospectively analyze the data of patients with primary retroperitoneal liposarcoma in a single Asian large-volume sarcoma center and to establish nomograms focused on PRLPS for predicting progression-free survival (PFS) and overall survival (OS). METHODS: A total of 211 patients treated surgically for primary, non-metastatic retroperitoneal liposarcoma during 2009–2021 were identified, and clinicopathologic variables were analyzed. PFS and OS nomograms were built based on variables selected by multivariable analysis. The discriminative and predictive ability of the nomogram was assessed by concordance index and calibration curve. RESULTS: The median follow-up time was 25 months. A total of 117 (56%) were well-differentiated, 78 (37%) were dedifferentiated, 13 (6%) were myxoid, and 3 (1%) were pleomorphic morphology. Compared to the western population cohort reported by the Memorial Sloan-Kettering Cancer Center, the median age of patients in this cohort was younger (57 vs. 63 years), the tumor burden was lower (20 vs. 26 cm), and the proportion of patients with R0 or R1 resection was higher (97% vs. 81%). The 5-year PFS rate was 49%, and factors independently associated with PFS were symptoms at visit, preoperative needle biopsy, histologic subtypes, and postoperative hospital stay. The 5-year OS rate was 72%. American Society of Anesthesiologists Physical Status and Clavien-Dindo classification were independently associated with OS. The concordance indexes for PFS and OS nomograms were 0.702 and 0.757, respectively. The calibration plots were excellent. CONCLUSIONS: The proposed nomogram provided a favorable reference for the treatment of primary retroperitoneal liposarcoma patients.
format Online
Article
Text
id pubmed-8790090
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-87900902022-01-27 Prognostic Factor Analysis and Nomogram Construction of Primary Retroperitoneal Liposarcoma: A Review of 10 Years of Treatment Experience in a Single Asian Cohort of 211 Cases Zhuang, Aobo Zhuang, Aojia Wu, Qian Lu, Weiqi Tong, Hanxing Zhang, Yong Front Oncol Oncology OBJECTIVE: This study intended to retrospectively analyze the data of patients with primary retroperitoneal liposarcoma in a single Asian large-volume sarcoma center and to establish nomograms focused on PRLPS for predicting progression-free survival (PFS) and overall survival (OS). METHODS: A total of 211 patients treated surgically for primary, non-metastatic retroperitoneal liposarcoma during 2009–2021 were identified, and clinicopathologic variables were analyzed. PFS and OS nomograms were built based on variables selected by multivariable analysis. The discriminative and predictive ability of the nomogram was assessed by concordance index and calibration curve. RESULTS: The median follow-up time was 25 months. A total of 117 (56%) were well-differentiated, 78 (37%) were dedifferentiated, 13 (6%) were myxoid, and 3 (1%) were pleomorphic morphology. Compared to the western population cohort reported by the Memorial Sloan-Kettering Cancer Center, the median age of patients in this cohort was younger (57 vs. 63 years), the tumor burden was lower (20 vs. 26 cm), and the proportion of patients with R0 or R1 resection was higher (97% vs. 81%). The 5-year PFS rate was 49%, and factors independently associated with PFS were symptoms at visit, preoperative needle biopsy, histologic subtypes, and postoperative hospital stay. The 5-year OS rate was 72%. American Society of Anesthesiologists Physical Status and Clavien-Dindo classification were independently associated with OS. The concordance indexes for PFS and OS nomograms were 0.702 and 0.757, respectively. The calibration plots were excellent. CONCLUSIONS: The proposed nomogram provided a favorable reference for the treatment of primary retroperitoneal liposarcoma patients. Frontiers Media S.A. 2022-01-12 /pmc/articles/PMC8790090/ /pubmed/35096578 http://dx.doi.org/10.3389/fonc.2021.777647 Text en Copyright © 2022 Zhuang, Zhuang, Wu, Lu, Tong and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhuang, Aobo
Zhuang, Aojia
Wu, Qian
Lu, Weiqi
Tong, Hanxing
Zhang, Yong
Prognostic Factor Analysis and Nomogram Construction of Primary Retroperitoneal Liposarcoma: A Review of 10 Years of Treatment Experience in a Single Asian Cohort of 211 Cases
title Prognostic Factor Analysis and Nomogram Construction of Primary Retroperitoneal Liposarcoma: A Review of 10 Years of Treatment Experience in a Single Asian Cohort of 211 Cases
title_full Prognostic Factor Analysis and Nomogram Construction of Primary Retroperitoneal Liposarcoma: A Review of 10 Years of Treatment Experience in a Single Asian Cohort of 211 Cases
title_fullStr Prognostic Factor Analysis and Nomogram Construction of Primary Retroperitoneal Liposarcoma: A Review of 10 Years of Treatment Experience in a Single Asian Cohort of 211 Cases
title_full_unstemmed Prognostic Factor Analysis and Nomogram Construction of Primary Retroperitoneal Liposarcoma: A Review of 10 Years of Treatment Experience in a Single Asian Cohort of 211 Cases
title_short Prognostic Factor Analysis and Nomogram Construction of Primary Retroperitoneal Liposarcoma: A Review of 10 Years of Treatment Experience in a Single Asian Cohort of 211 Cases
title_sort prognostic factor analysis and nomogram construction of primary retroperitoneal liposarcoma: a review of 10 years of treatment experience in a single asian cohort of 211 cases
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790090/
https://www.ncbi.nlm.nih.gov/pubmed/35096578
http://dx.doi.org/10.3389/fonc.2021.777647
work_keys_str_mv AT zhuangaobo prognosticfactoranalysisandnomogramconstructionofprimaryretroperitonealliposarcomaareviewof10yearsoftreatmentexperienceinasingleasiancohortof211cases
AT zhuangaojia prognosticfactoranalysisandnomogramconstructionofprimaryretroperitonealliposarcomaareviewof10yearsoftreatmentexperienceinasingleasiancohortof211cases
AT wuqian prognosticfactoranalysisandnomogramconstructionofprimaryretroperitonealliposarcomaareviewof10yearsoftreatmentexperienceinasingleasiancohortof211cases
AT luweiqi prognosticfactoranalysisandnomogramconstructionofprimaryretroperitonealliposarcomaareviewof10yearsoftreatmentexperienceinasingleasiancohortof211cases
AT tonghanxing prognosticfactoranalysisandnomogramconstructionofprimaryretroperitonealliposarcomaareviewof10yearsoftreatmentexperienceinasingleasiancohortof211cases
AT zhangyong prognosticfactoranalysisandnomogramconstructionofprimaryretroperitonealliposarcomaareviewof10yearsoftreatmentexperienceinasingleasiancohortof211cases