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Meningococcal Carriage in ‘Men Having Sex With Men’ With Pharyngeal Gonorrhoea
We assessed the characteristics of Neisseria meningitidis pharyngeal carriage in a cohort of ‘men having sex with men’, including patients with pharyngeal Neisseria gonorrhoeae infection. In the period 2017-2019, among all the oropharyngeal samples tested for gonorrhoea from MSM attending a STI Clin...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790146/ https://www.ncbi.nlm.nih.gov/pubmed/35096648 http://dx.doi.org/10.3389/fcimb.2021.798575 |
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author | Morselli, Sara Gaspari, Valeria Cantiani, Alessia Salvo, Melissa Foschi, Claudio Lazzarotto, Tiziana Marangoni, Antonella |
author_facet | Morselli, Sara Gaspari, Valeria Cantiani, Alessia Salvo, Melissa Foschi, Claudio Lazzarotto, Tiziana Marangoni, Antonella |
author_sort | Morselli, Sara |
collection | PubMed |
description | We assessed the characteristics of Neisseria meningitidis pharyngeal carriage in a cohort of ‘men having sex with men’, including patients with pharyngeal Neisseria gonorrhoeae infection. In the period 2017-2019, among all the oropharyngeal samples tested for gonorrhoea from MSM attending a STI Clinic in Bologna (Italy), we randomly selected 244 N. gonorrhoeae-positive samples and 403 negatives (n=647). Pharyngeal specimens were tested for N. meningitidis presence, by the detection of sodC gene. N. meningitidis-positive samples were further grouped by PCR tests for the major invasive genogroups (i.e., A, B, C, W, and Y). A molecular assay, targeting capsule transporter gene, was used to determine meningococcal capsular status. Overall, 75.8% (491/647) of samples tested positive for sodC gene, indicating a pharyngeal meningococcal carriage. Meningococcal colonisation was significantly more frequent in younger subjects (P=0.009), with no association with HIV infection. Non-groupable meningococci represented most of pharyngeal carriages (about 71%). The commonest N. meningitidis serogroup was B (23.6%), followed by C (2.1%), Y (1.8%) and W (1.1%). Meningococci were often characterized by the genetic potential of capsule production. Interestingly, a negative association between N. meningitidis and N. gonorrhoeae was found: pharyngeal gonorrhoea was significantly more present in patients without meningococcal carriage (P=0.03). Although preliminary, our data added knowledge on the epidemiology of meningococcal carriage in MSM communities at high risk of gonococcal infections, gaining new insights into the interactions/dynamics between N. meningitidis and N. gonorrhoeae. |
format | Online Article Text |
id | pubmed-8790146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87901462022-01-27 Meningococcal Carriage in ‘Men Having Sex With Men’ With Pharyngeal Gonorrhoea Morselli, Sara Gaspari, Valeria Cantiani, Alessia Salvo, Melissa Foschi, Claudio Lazzarotto, Tiziana Marangoni, Antonella Front Cell Infect Microbiol Cellular and Infection Microbiology We assessed the characteristics of Neisseria meningitidis pharyngeal carriage in a cohort of ‘men having sex with men’, including patients with pharyngeal Neisseria gonorrhoeae infection. In the period 2017-2019, among all the oropharyngeal samples tested for gonorrhoea from MSM attending a STI Clinic in Bologna (Italy), we randomly selected 244 N. gonorrhoeae-positive samples and 403 negatives (n=647). Pharyngeal specimens were tested for N. meningitidis presence, by the detection of sodC gene. N. meningitidis-positive samples were further grouped by PCR tests for the major invasive genogroups (i.e., A, B, C, W, and Y). A molecular assay, targeting capsule transporter gene, was used to determine meningococcal capsular status. Overall, 75.8% (491/647) of samples tested positive for sodC gene, indicating a pharyngeal meningococcal carriage. Meningococcal colonisation was significantly more frequent in younger subjects (P=0.009), with no association with HIV infection. Non-groupable meningococci represented most of pharyngeal carriages (about 71%). The commonest N. meningitidis serogroup was B (23.6%), followed by C (2.1%), Y (1.8%) and W (1.1%). Meningococci were often characterized by the genetic potential of capsule production. Interestingly, a negative association between N. meningitidis and N. gonorrhoeae was found: pharyngeal gonorrhoea was significantly more present in patients without meningococcal carriage (P=0.03). Although preliminary, our data added knowledge on the epidemiology of meningococcal carriage in MSM communities at high risk of gonococcal infections, gaining new insights into the interactions/dynamics between N. meningitidis and N. gonorrhoeae. Frontiers Media S.A. 2022-01-12 /pmc/articles/PMC8790146/ /pubmed/35096648 http://dx.doi.org/10.3389/fcimb.2021.798575 Text en Copyright © 2022 Morselli, Gaspari, Cantiani, Salvo, Foschi, Lazzarotto and Marangoni https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Morselli, Sara Gaspari, Valeria Cantiani, Alessia Salvo, Melissa Foschi, Claudio Lazzarotto, Tiziana Marangoni, Antonella Meningococcal Carriage in ‘Men Having Sex With Men’ With Pharyngeal Gonorrhoea |
title | Meningococcal Carriage in ‘Men Having Sex With Men’ With Pharyngeal Gonorrhoea |
title_full | Meningococcal Carriage in ‘Men Having Sex With Men’ With Pharyngeal Gonorrhoea |
title_fullStr | Meningococcal Carriage in ‘Men Having Sex With Men’ With Pharyngeal Gonorrhoea |
title_full_unstemmed | Meningococcal Carriage in ‘Men Having Sex With Men’ With Pharyngeal Gonorrhoea |
title_short | Meningococcal Carriage in ‘Men Having Sex With Men’ With Pharyngeal Gonorrhoea |
title_sort | meningococcal carriage in ‘men having sex with men’ with pharyngeal gonorrhoea |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790146/ https://www.ncbi.nlm.nih.gov/pubmed/35096648 http://dx.doi.org/10.3389/fcimb.2021.798575 |
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