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Meningococcal Carriage in ‘Men Having Sex With Men’ With Pharyngeal Gonorrhoea

We assessed the characteristics of Neisseria meningitidis pharyngeal carriage in a cohort of ‘men having sex with men’, including patients with pharyngeal Neisseria gonorrhoeae infection. In the period 2017-2019, among all the oropharyngeal samples tested for gonorrhoea from MSM attending a STI Clin...

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Autores principales: Morselli, Sara, Gaspari, Valeria, Cantiani, Alessia, Salvo, Melissa, Foschi, Claudio, Lazzarotto, Tiziana, Marangoni, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790146/
https://www.ncbi.nlm.nih.gov/pubmed/35096648
http://dx.doi.org/10.3389/fcimb.2021.798575
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author Morselli, Sara
Gaspari, Valeria
Cantiani, Alessia
Salvo, Melissa
Foschi, Claudio
Lazzarotto, Tiziana
Marangoni, Antonella
author_facet Morselli, Sara
Gaspari, Valeria
Cantiani, Alessia
Salvo, Melissa
Foschi, Claudio
Lazzarotto, Tiziana
Marangoni, Antonella
author_sort Morselli, Sara
collection PubMed
description We assessed the characteristics of Neisseria meningitidis pharyngeal carriage in a cohort of ‘men having sex with men’, including patients with pharyngeal Neisseria gonorrhoeae infection. In the period 2017-2019, among all the oropharyngeal samples tested for gonorrhoea from MSM attending a STI Clinic in Bologna (Italy), we randomly selected 244 N. gonorrhoeae-positive samples and 403 negatives (n=647). Pharyngeal specimens were tested for N. meningitidis presence, by the detection of sodC gene. N. meningitidis-positive samples were further grouped by PCR tests for the major invasive genogroups (i.e., A, B, C, W, and Y). A molecular assay, targeting capsule transporter gene, was used to determine meningococcal capsular status. Overall, 75.8% (491/647) of samples tested positive for sodC gene, indicating a pharyngeal meningococcal carriage. Meningococcal colonisation was significantly more frequent in younger subjects (P=0.009), with no association with HIV infection. Non-groupable meningococci represented most of pharyngeal carriages (about 71%). The commonest N. meningitidis serogroup was B (23.6%), followed by C (2.1%), Y (1.8%) and W (1.1%). Meningococci were often characterized by the genetic potential of capsule production. Interestingly, a negative association between N. meningitidis and N. gonorrhoeae was found: pharyngeal gonorrhoea was significantly more present in patients without meningococcal carriage (P=0.03). Although preliminary, our data added knowledge on the epidemiology of meningococcal carriage in MSM communities at high risk of gonococcal infections, gaining new insights into the interactions/dynamics between N. meningitidis and N. gonorrhoeae.
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spelling pubmed-87901462022-01-27 Meningococcal Carriage in ‘Men Having Sex With Men’ With Pharyngeal Gonorrhoea Morselli, Sara Gaspari, Valeria Cantiani, Alessia Salvo, Melissa Foschi, Claudio Lazzarotto, Tiziana Marangoni, Antonella Front Cell Infect Microbiol Cellular and Infection Microbiology We assessed the characteristics of Neisseria meningitidis pharyngeal carriage in a cohort of ‘men having sex with men’, including patients with pharyngeal Neisseria gonorrhoeae infection. In the period 2017-2019, among all the oropharyngeal samples tested for gonorrhoea from MSM attending a STI Clinic in Bologna (Italy), we randomly selected 244 N. gonorrhoeae-positive samples and 403 negatives (n=647). Pharyngeal specimens were tested for N. meningitidis presence, by the detection of sodC gene. N. meningitidis-positive samples were further grouped by PCR tests for the major invasive genogroups (i.e., A, B, C, W, and Y). A molecular assay, targeting capsule transporter gene, was used to determine meningococcal capsular status. Overall, 75.8% (491/647) of samples tested positive for sodC gene, indicating a pharyngeal meningococcal carriage. Meningococcal colonisation was significantly more frequent in younger subjects (P=0.009), with no association with HIV infection. Non-groupable meningococci represented most of pharyngeal carriages (about 71%). The commonest N. meningitidis serogroup was B (23.6%), followed by C (2.1%), Y (1.8%) and W (1.1%). Meningococci were often characterized by the genetic potential of capsule production. Interestingly, a negative association between N. meningitidis and N. gonorrhoeae was found: pharyngeal gonorrhoea was significantly more present in patients without meningococcal carriage (P=0.03). Although preliminary, our data added knowledge on the epidemiology of meningococcal carriage in MSM communities at high risk of gonococcal infections, gaining new insights into the interactions/dynamics between N. meningitidis and N. gonorrhoeae. Frontiers Media S.A. 2022-01-12 /pmc/articles/PMC8790146/ /pubmed/35096648 http://dx.doi.org/10.3389/fcimb.2021.798575 Text en Copyright © 2022 Morselli, Gaspari, Cantiani, Salvo, Foschi, Lazzarotto and Marangoni https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Morselli, Sara
Gaspari, Valeria
Cantiani, Alessia
Salvo, Melissa
Foschi, Claudio
Lazzarotto, Tiziana
Marangoni, Antonella
Meningococcal Carriage in ‘Men Having Sex With Men’ With Pharyngeal Gonorrhoea
title Meningococcal Carriage in ‘Men Having Sex With Men’ With Pharyngeal Gonorrhoea
title_full Meningococcal Carriage in ‘Men Having Sex With Men’ With Pharyngeal Gonorrhoea
title_fullStr Meningococcal Carriage in ‘Men Having Sex With Men’ With Pharyngeal Gonorrhoea
title_full_unstemmed Meningococcal Carriage in ‘Men Having Sex With Men’ With Pharyngeal Gonorrhoea
title_short Meningococcal Carriage in ‘Men Having Sex With Men’ With Pharyngeal Gonorrhoea
title_sort meningococcal carriage in ‘men having sex with men’ with pharyngeal gonorrhoea
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790146/
https://www.ncbi.nlm.nih.gov/pubmed/35096648
http://dx.doi.org/10.3389/fcimb.2021.798575
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