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Paclitaxel may be a risk factor for retinal phototoxicity

PURPOSE: To report the first case, to our knowledge, of suspected paclitaxel induced phototoxic maculopathy following vitrectomy surgery. OBSERVATIONS: A 62-year-old phakic female receiving paclitaxel therapy for ovarian carcinoma presented with a best corrected visual acuity (BCVA) of 20/40 OD with...

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Autores principales: Malcolm, Jonathan, Lune Wong, Caroline Oi, Ching, Jared, Saidkasimova, Shohista
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790282/
https://www.ncbi.nlm.nih.gov/pubmed/35112024
http://dx.doi.org/10.1016/j.ajoc.2022.101292
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author Malcolm, Jonathan
Lune Wong, Caroline Oi
Ching, Jared
Saidkasimova, Shohista
author_facet Malcolm, Jonathan
Lune Wong, Caroline Oi
Ching, Jared
Saidkasimova, Shohista
author_sort Malcolm, Jonathan
collection PubMed
description PURPOSE: To report the first case, to our knowledge, of suspected paclitaxel induced phototoxic maculopathy following vitrectomy surgery. OBSERVATIONS: A 62-year-old phakic female receiving paclitaxel therapy for ovarian carcinoma presented with a best corrected visual acuity (BCVA) of 20/40 OD with an epiretinal membrane (ERM) and lamellar macular hole on spectral domain optical coherence tomography (SD-OCT). The patient underwent an uneventful pars plana vitrectomy with ERM peel using standard illumination and vitrectomy settings. Membrane Blue Dual (DORC, Netherlands) was used to stain the ERM. Two weeks post-operatively, the patient presented with a reduced BCVA of 20/200 in the operated eye. Fluorescein and indocyanine green angiography revealed right sided patchy hypofluorescence and hyperfluorescence secondary to retinal pigment epithelium changes with intact choroidal and retinal vasculature. SD-OCT and fundoscopy showed right sided loss of ellipsoid layer, increased reflectivity within the retinal pigmented epithelium and subretinal fibrosis without cystoid macular edema. Four months post-operatively her vision had stabilized to 20/160; unfortunately, the patient was palliated a month later due to ovarian carcinoma progression. CONCLUSIONS: A number of drugs are known to increase photosensitivity to solar and artificial forms of radiation. Paclitaxel use has been widely reported to cause dermatological photosensitivity. We report a case of suspected paclitaxel induced phototoxic maculopathy following endoillumination during vitrectomy surgery.
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spelling pubmed-87902822022-02-01 Paclitaxel may be a risk factor for retinal phototoxicity Malcolm, Jonathan Lune Wong, Caroline Oi Ching, Jared Saidkasimova, Shohista Am J Ophthalmol Case Rep Case Report PURPOSE: To report the first case, to our knowledge, of suspected paclitaxel induced phototoxic maculopathy following vitrectomy surgery. OBSERVATIONS: A 62-year-old phakic female receiving paclitaxel therapy for ovarian carcinoma presented with a best corrected visual acuity (BCVA) of 20/40 OD with an epiretinal membrane (ERM) and lamellar macular hole on spectral domain optical coherence tomography (SD-OCT). The patient underwent an uneventful pars plana vitrectomy with ERM peel using standard illumination and vitrectomy settings. Membrane Blue Dual (DORC, Netherlands) was used to stain the ERM. Two weeks post-operatively, the patient presented with a reduced BCVA of 20/200 in the operated eye. Fluorescein and indocyanine green angiography revealed right sided patchy hypofluorescence and hyperfluorescence secondary to retinal pigment epithelium changes with intact choroidal and retinal vasculature. SD-OCT and fundoscopy showed right sided loss of ellipsoid layer, increased reflectivity within the retinal pigmented epithelium and subretinal fibrosis without cystoid macular edema. Four months post-operatively her vision had stabilized to 20/160; unfortunately, the patient was palliated a month later due to ovarian carcinoma progression. CONCLUSIONS: A number of drugs are known to increase photosensitivity to solar and artificial forms of radiation. Paclitaxel use has been widely reported to cause dermatological photosensitivity. We report a case of suspected paclitaxel induced phototoxic maculopathy following endoillumination during vitrectomy surgery. Elsevier 2022-01-20 /pmc/articles/PMC8790282/ /pubmed/35112024 http://dx.doi.org/10.1016/j.ajoc.2022.101292 Text en © 2022 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Malcolm, Jonathan
Lune Wong, Caroline Oi
Ching, Jared
Saidkasimova, Shohista
Paclitaxel may be a risk factor for retinal phototoxicity
title Paclitaxel may be a risk factor for retinal phototoxicity
title_full Paclitaxel may be a risk factor for retinal phototoxicity
title_fullStr Paclitaxel may be a risk factor for retinal phototoxicity
title_full_unstemmed Paclitaxel may be a risk factor for retinal phototoxicity
title_short Paclitaxel may be a risk factor for retinal phototoxicity
title_sort paclitaxel may be a risk factor for retinal phototoxicity
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790282/
https://www.ncbi.nlm.nih.gov/pubmed/35112024
http://dx.doi.org/10.1016/j.ajoc.2022.101292
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