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Application of an organotypic ocular perfusion model to assess intravitreal drug distribution in human and animal eyes

Intravitreal (ITV) drug delivery is a new cornerstone for retinal therapeutics. Yet, predicting the disposition of formulations in the human eye remains a major translational hurdle. A prominent, but poorly understood, issue in pre-clinical ITV toxicity studies is unintended particle movements to th...

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Detalles Bibliográficos
Autores principales:	Chan, D., Won, G. J., Read, A. T., Ethier, C. R., Thackaberry, E., Crowell, S. R., Booler, H., Bantseev, V., Sivak, J. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2022
Materias:	Life Sciences–Engineering interface
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790337/ https://www.ncbi.nlm.nih.gov/pubmed/35078337 http://dx.doi.org/10.1098/rsif.2021.0734

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