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Multiple roles of ribosomal antimicrobial peptides in tackling global antimicrobial resistance

In the last century, conventional antibiotics have played a significant role in global healthcare. Antibiotics support the body in controlling bacterial infection and simultaneously increase the tendency of drug resistance. Consequently, there is a severe concern regarding the regression of the anti...

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Autores principales: Luong, Huy Xuan, Ngan, Hoa Doan, Thi Phuong, Hai Bui, Quoc, Thang Nguyen, Tung, Truong Thanh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790363/
https://www.ncbi.nlm.nih.gov/pubmed/35116161
http://dx.doi.org/10.1098/rsos.211583
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author Luong, Huy Xuan
Ngan, Hoa Doan
Thi Phuong, Hai Bui
Quoc, Thang Nguyen
Tung, Truong Thanh
author_facet Luong, Huy Xuan
Ngan, Hoa Doan
Thi Phuong, Hai Bui
Quoc, Thang Nguyen
Tung, Truong Thanh
author_sort Luong, Huy Xuan
collection PubMed
description In the last century, conventional antibiotics have played a significant role in global healthcare. Antibiotics support the body in controlling bacterial infection and simultaneously increase the tendency of drug resistance. Consequently, there is a severe concern regarding the regression of the antibiotic era. Despite the use of antibiotics, host defence systems are vital in fighting infectious diseases. In fact, the expression of ribosomal antimicrobial peptides (AMPs) has been crucial in the evolution of innate host defences and has been irreplaceable to date. Therefore, this valuable source is considered to have great potential in tackling the antimicrobial resistance (AMR) crisis. Furthermore, the possibility of bacterial resistance to AMPs has been intensively investigated. Here, we summarize all aspects related to the multiple applications of ribosomal AMPs and their derivatives in combating AMR.
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spelling pubmed-87903632022-02-02 Multiple roles of ribosomal antimicrobial peptides in tackling global antimicrobial resistance Luong, Huy Xuan Ngan, Hoa Doan Thi Phuong, Hai Bui Quoc, Thang Nguyen Tung, Truong Thanh R Soc Open Sci Chemistry In the last century, conventional antibiotics have played a significant role in global healthcare. Antibiotics support the body in controlling bacterial infection and simultaneously increase the tendency of drug resistance. Consequently, there is a severe concern regarding the regression of the antibiotic era. Despite the use of antibiotics, host defence systems are vital in fighting infectious diseases. In fact, the expression of ribosomal antimicrobial peptides (AMPs) has been crucial in the evolution of innate host defences and has been irreplaceable to date. Therefore, this valuable source is considered to have great potential in tackling the antimicrobial resistance (AMR) crisis. Furthermore, the possibility of bacterial resistance to AMPs has been intensively investigated. Here, we summarize all aspects related to the multiple applications of ribosomal AMPs and their derivatives in combating AMR. The Royal Society 2022-01-26 /pmc/articles/PMC8790363/ /pubmed/35116161 http://dx.doi.org/10.1098/rsos.211583 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Chemistry
Luong, Huy Xuan
Ngan, Hoa Doan
Thi Phuong, Hai Bui
Quoc, Thang Nguyen
Tung, Truong Thanh
Multiple roles of ribosomal antimicrobial peptides in tackling global antimicrobial resistance
title Multiple roles of ribosomal antimicrobial peptides in tackling global antimicrobial resistance
title_full Multiple roles of ribosomal antimicrobial peptides in tackling global antimicrobial resistance
title_fullStr Multiple roles of ribosomal antimicrobial peptides in tackling global antimicrobial resistance
title_full_unstemmed Multiple roles of ribosomal antimicrobial peptides in tackling global antimicrobial resistance
title_short Multiple roles of ribosomal antimicrobial peptides in tackling global antimicrobial resistance
title_sort multiple roles of ribosomal antimicrobial peptides in tackling global antimicrobial resistance
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790363/
https://www.ncbi.nlm.nih.gov/pubmed/35116161
http://dx.doi.org/10.1098/rsos.211583
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