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Molecular regulatory mechanism of ferroptosis and its role in gastrointestinal oncology: Progress and updates
Gastrointestinal (GI) tumors, including liver, pancreatic, gastric, and colorectal cancers, have a high incidence rate and low survival rate due to the lack of effective therapeutic methods and frequent relapses. Surgery and postoperative chemoradiotherapy have largely reduced the fatality rates for...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790407/ https://www.ncbi.nlm.nih.gov/pubmed/35116100 http://dx.doi.org/10.4251/wjgo.v14.i1.1 |
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author | Yang, Fan Sun, Si-Yu Wang, Sheng Guo, Jin-Tao Liu, Xiang Ge, Nan Wang, Guo-Xin |
author_facet | Yang, Fan Sun, Si-Yu Wang, Sheng Guo, Jin-Tao Liu, Xiang Ge, Nan Wang, Guo-Xin |
author_sort | Yang, Fan |
collection | PubMed |
description | Gastrointestinal (GI) tumors, including liver, pancreatic, gastric, and colorectal cancers, have a high incidence rate and low survival rate due to the lack of effective therapeutic methods and frequent relapses. Surgery and postoperative chemoradiotherapy have largely reduced the fatality rates for most GI tumors, but these therapeutic approaches result in poor prognoses due to severe adverse reactions and the development of drug resistance. Recent studies have shown that ferroptosis plays an important role in the onset and progression of GI tumors. Ferroptosis is a new non-apoptotic form of cell death, which is iron-dependent, non-apoptotic cell death characterized by the accumulation of lipid reactive oxygen species (ROS). The activation of ferroptosis can lead to tumor cell death. Thus, regulating ferroptosis in tumor cells may become a new therapeutic approach for tumors, making it become a research hotspot. Current studies suggest that ferroptosis is mainly triggered by the accumulation of lipid ROS. Furthermore, several studies have indicated that ferroptosis may be a new approach for the treatment of GI tumors. Here, we review current research progress on the mechanism of ferroptosis, current inducers and inhibitors of ferroptosis, and the role of ferroptosis in GI tumors to propose new methods for the treatment of such tumors. |
format | Online Article Text |
id | pubmed-8790407 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-87904072022-02-02 Molecular regulatory mechanism of ferroptosis and its role in gastrointestinal oncology: Progress and updates Yang, Fan Sun, Si-Yu Wang, Sheng Guo, Jin-Tao Liu, Xiang Ge, Nan Wang, Guo-Xin World J Gastrointest Oncol Review Gastrointestinal (GI) tumors, including liver, pancreatic, gastric, and colorectal cancers, have a high incidence rate and low survival rate due to the lack of effective therapeutic methods and frequent relapses. Surgery and postoperative chemoradiotherapy have largely reduced the fatality rates for most GI tumors, but these therapeutic approaches result in poor prognoses due to severe adverse reactions and the development of drug resistance. Recent studies have shown that ferroptosis plays an important role in the onset and progression of GI tumors. Ferroptosis is a new non-apoptotic form of cell death, which is iron-dependent, non-apoptotic cell death characterized by the accumulation of lipid reactive oxygen species (ROS). The activation of ferroptosis can lead to tumor cell death. Thus, regulating ferroptosis in tumor cells may become a new therapeutic approach for tumors, making it become a research hotspot. Current studies suggest that ferroptosis is mainly triggered by the accumulation of lipid ROS. Furthermore, several studies have indicated that ferroptosis may be a new approach for the treatment of GI tumors. Here, we review current research progress on the mechanism of ferroptosis, current inducers and inhibitors of ferroptosis, and the role of ferroptosis in GI tumors to propose new methods for the treatment of such tumors. Baishideng Publishing Group Inc 2022-01-15 2022-01-15 /pmc/articles/PMC8790407/ /pubmed/35116100 http://dx.doi.org/10.4251/wjgo.v14.i1.1 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Review Yang, Fan Sun, Si-Yu Wang, Sheng Guo, Jin-Tao Liu, Xiang Ge, Nan Wang, Guo-Xin Molecular regulatory mechanism of ferroptosis and its role in gastrointestinal oncology: Progress and updates |
title | Molecular regulatory mechanism of ferroptosis and its role in gastrointestinal oncology: Progress and updates |
title_full | Molecular regulatory mechanism of ferroptosis and its role in gastrointestinal oncology: Progress and updates |
title_fullStr | Molecular regulatory mechanism of ferroptosis and its role in gastrointestinal oncology: Progress and updates |
title_full_unstemmed | Molecular regulatory mechanism of ferroptosis and its role in gastrointestinal oncology: Progress and updates |
title_short | Molecular regulatory mechanism of ferroptosis and its role in gastrointestinal oncology: Progress and updates |
title_sort | molecular regulatory mechanism of ferroptosis and its role in gastrointestinal oncology: progress and updates |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790407/ https://www.ncbi.nlm.nih.gov/pubmed/35116100 http://dx.doi.org/10.4251/wjgo.v14.i1.1 |
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