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Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model

BACKGROUND: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in the world. Tumor removal remains the preferred frontline treatment; however, effective non-surgical interventions remain a high priority. 5-fluorouracil (5-FU) is a widely used chemotherapy agent, and molecula...

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Autores principales: Asgharzadeh, Fereshteh, Tarnava, Alex, Mostafapour, Asma, Khazaei, Majid, LeBaron, Tyler W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790422/
https://www.ncbi.nlm.nih.gov/pubmed/35116114
http://dx.doi.org/10.4251/wjgo.v14.i1.242
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author Asgharzadeh, Fereshteh
Tarnava, Alex
Mostafapour, Asma
Khazaei, Majid
LeBaron, Tyler W
author_facet Asgharzadeh, Fereshteh
Tarnava, Alex
Mostafapour, Asma
Khazaei, Majid
LeBaron, Tyler W
author_sort Asgharzadeh, Fereshteh
collection PubMed
description BACKGROUND: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in the world. Tumor removal remains the preferred frontline treatment; however, effective non-surgical interventions remain a high priority. 5-fluorouracil (5-FU) is a widely used chemotherapy agent, and molecular hydrogen (H(2)) has been recognized for its antioxidant and anti-inflammatory effects, with research also suggesting its potential anti-tumor effects. Therefore, H(2) dissolved in water [hydrogen-rich water (HRW)], with or without 5-FU, may present itself as a novel therapeutic for CRC. AIM: To investigate the effects of HRW, with or without 5-FU, as a novel therapeutic for CRC. METHODS: CRC was induced in the left flank of inbred Balb/c mice. A total of 24 mice bearing tumors were randomly divided into four groups (n = 6 per group) and treated as follows: (1) Control group; (2) 5-FU group that received intraperitoneal injection of 5-FU (5 mg/kg) every other day; (3) H(2) group that received HRW, created and delivered via dissolving the H(2)-generating tablet in the animals’ drinking water, with 200 μL also delivered by oral gavage; and (4) The combination group, H(2 ) (administered in same way as for group three) combined with 5-FU administered same way as group two. RESULTS: Administration of HRW + 5-FU significantly improved tumor weight, tumor size, collagen content and fibrosis as compared to the CRC control group. Specifically, HRW attenuated oxidative stress (OS) and potentiated antioxidant activity (AA), whereas 5-FU treatment exacerbated OS and blunted AA. The combination of HRW + 5-FU significantly reduced tumor weight and size, as well as reduced collagen deposition and the degree of fibrosis, while further increasing OS and decreasing AA compared to administration of 5-FU alone. CONCLUSION: Administration of HRW, with or without 5-FU, may serve as a therapeutic for treating CRC.
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spelling pubmed-87904222022-02-02 Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model Asgharzadeh, Fereshteh Tarnava, Alex Mostafapour, Asma Khazaei, Majid LeBaron, Tyler W World J Gastrointest Oncol Basic Study BACKGROUND: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in the world. Tumor removal remains the preferred frontline treatment; however, effective non-surgical interventions remain a high priority. 5-fluorouracil (5-FU) is a widely used chemotherapy agent, and molecular hydrogen (H(2)) has been recognized for its antioxidant and anti-inflammatory effects, with research also suggesting its potential anti-tumor effects. Therefore, H(2) dissolved in water [hydrogen-rich water (HRW)], with or without 5-FU, may present itself as a novel therapeutic for CRC. AIM: To investigate the effects of HRW, with or without 5-FU, as a novel therapeutic for CRC. METHODS: CRC was induced in the left flank of inbred Balb/c mice. A total of 24 mice bearing tumors were randomly divided into four groups (n = 6 per group) and treated as follows: (1) Control group; (2) 5-FU group that received intraperitoneal injection of 5-FU (5 mg/kg) every other day; (3) H(2) group that received HRW, created and delivered via dissolving the H(2)-generating tablet in the animals’ drinking water, with 200 μL also delivered by oral gavage; and (4) The combination group, H(2 ) (administered in same way as for group three) combined with 5-FU administered same way as group two. RESULTS: Administration of HRW + 5-FU significantly improved tumor weight, tumor size, collagen content and fibrosis as compared to the CRC control group. Specifically, HRW attenuated oxidative stress (OS) and potentiated antioxidant activity (AA), whereas 5-FU treatment exacerbated OS and blunted AA. The combination of HRW + 5-FU significantly reduced tumor weight and size, as well as reduced collagen deposition and the degree of fibrosis, while further increasing OS and decreasing AA compared to administration of 5-FU alone. CONCLUSION: Administration of HRW, with or without 5-FU, may serve as a therapeutic for treating CRC. Baishideng Publishing Group Inc 2022-01-15 2022-01-15 /pmc/articles/PMC8790422/ /pubmed/35116114 http://dx.doi.org/10.4251/wjgo.v14.i1.242 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Basic Study
Asgharzadeh, Fereshteh
Tarnava, Alex
Mostafapour, Asma
Khazaei, Majid
LeBaron, Tyler W
Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model
title Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model
title_full Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model
title_fullStr Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model
title_full_unstemmed Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model
title_short Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model
title_sort hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model
topic Basic Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790422/
https://www.ncbi.nlm.nih.gov/pubmed/35116114
http://dx.doi.org/10.4251/wjgo.v14.i1.242
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