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Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model
BACKGROUND: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in the world. Tumor removal remains the preferred frontline treatment; however, effective non-surgical interventions remain a high priority. 5-fluorouracil (5-FU) is a widely used chemotherapy agent, and molecula...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790422/ https://www.ncbi.nlm.nih.gov/pubmed/35116114 http://dx.doi.org/10.4251/wjgo.v14.i1.242 |
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author | Asgharzadeh, Fereshteh Tarnava, Alex Mostafapour, Asma Khazaei, Majid LeBaron, Tyler W |
author_facet | Asgharzadeh, Fereshteh Tarnava, Alex Mostafapour, Asma Khazaei, Majid LeBaron, Tyler W |
author_sort | Asgharzadeh, Fereshteh |
collection | PubMed |
description | BACKGROUND: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in the world. Tumor removal remains the preferred frontline treatment; however, effective non-surgical interventions remain a high priority. 5-fluorouracil (5-FU) is a widely used chemotherapy agent, and molecular hydrogen (H(2)) has been recognized for its antioxidant and anti-inflammatory effects, with research also suggesting its potential anti-tumor effects. Therefore, H(2) dissolved in water [hydrogen-rich water (HRW)], with or without 5-FU, may present itself as a novel therapeutic for CRC. AIM: To investigate the effects of HRW, with or without 5-FU, as a novel therapeutic for CRC. METHODS: CRC was induced in the left flank of inbred Balb/c mice. A total of 24 mice bearing tumors were randomly divided into four groups (n = 6 per group) and treated as follows: (1) Control group; (2) 5-FU group that received intraperitoneal injection of 5-FU (5 mg/kg) every other day; (3) H(2) group that received HRW, created and delivered via dissolving the H(2)-generating tablet in the animals’ drinking water, with 200 μL also delivered by oral gavage; and (4) The combination group, H(2 ) (administered in same way as for group three) combined with 5-FU administered same way as group two. RESULTS: Administration of HRW + 5-FU significantly improved tumor weight, tumor size, collagen content and fibrosis as compared to the CRC control group. Specifically, HRW attenuated oxidative stress (OS) and potentiated antioxidant activity (AA), whereas 5-FU treatment exacerbated OS and blunted AA. The combination of HRW + 5-FU significantly reduced tumor weight and size, as well as reduced collagen deposition and the degree of fibrosis, while further increasing OS and decreasing AA compared to administration of 5-FU alone. CONCLUSION: Administration of HRW, with or without 5-FU, may serve as a therapeutic for treating CRC. |
format | Online Article Text |
id | pubmed-8790422 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-87904222022-02-02 Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model Asgharzadeh, Fereshteh Tarnava, Alex Mostafapour, Asma Khazaei, Majid LeBaron, Tyler W World J Gastrointest Oncol Basic Study BACKGROUND: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in the world. Tumor removal remains the preferred frontline treatment; however, effective non-surgical interventions remain a high priority. 5-fluorouracil (5-FU) is a widely used chemotherapy agent, and molecular hydrogen (H(2)) has been recognized for its antioxidant and anti-inflammatory effects, with research also suggesting its potential anti-tumor effects. Therefore, H(2) dissolved in water [hydrogen-rich water (HRW)], with or without 5-FU, may present itself as a novel therapeutic for CRC. AIM: To investigate the effects of HRW, with or without 5-FU, as a novel therapeutic for CRC. METHODS: CRC was induced in the left flank of inbred Balb/c mice. A total of 24 mice bearing tumors were randomly divided into four groups (n = 6 per group) and treated as follows: (1) Control group; (2) 5-FU group that received intraperitoneal injection of 5-FU (5 mg/kg) every other day; (3) H(2) group that received HRW, created and delivered via dissolving the H(2)-generating tablet in the animals’ drinking water, with 200 μL also delivered by oral gavage; and (4) The combination group, H(2 ) (administered in same way as for group three) combined with 5-FU administered same way as group two. RESULTS: Administration of HRW + 5-FU significantly improved tumor weight, tumor size, collagen content and fibrosis as compared to the CRC control group. Specifically, HRW attenuated oxidative stress (OS) and potentiated antioxidant activity (AA), whereas 5-FU treatment exacerbated OS and blunted AA. The combination of HRW + 5-FU significantly reduced tumor weight and size, as well as reduced collagen deposition and the degree of fibrosis, while further increasing OS and decreasing AA compared to administration of 5-FU alone. CONCLUSION: Administration of HRW, with or without 5-FU, may serve as a therapeutic for treating CRC. Baishideng Publishing Group Inc 2022-01-15 2022-01-15 /pmc/articles/PMC8790422/ /pubmed/35116114 http://dx.doi.org/10.4251/wjgo.v14.i1.242 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Basic Study Asgharzadeh, Fereshteh Tarnava, Alex Mostafapour, Asma Khazaei, Majid LeBaron, Tyler W Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model |
title | Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model |
title_full | Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model |
title_fullStr | Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model |
title_full_unstemmed | Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model |
title_short | Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model |
title_sort | hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model |
topic | Basic Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790422/ https://www.ncbi.nlm.nih.gov/pubmed/35116114 http://dx.doi.org/10.4251/wjgo.v14.i1.242 |
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