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Shaping the Sensory–Motor Network by Short-Term Unresolvable Sensory–Motor Mismatch

Learning from errors as the main mechanism for motor adaptation has two fundamental prerequisites: a mismatch between the intended and performed movement and the ability to adapt motor actions. Many neurological patients are limited in their ability to transfer an altered motor representation into m...

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Autores principales: Klingner, Carsten M., Kattlun, Fabian, Krolopp, Lena, Jochmann, Elisabeth, Volk, Gerd F., Brodoehl, Stefan, Guntinas-Lichius, Orlando, Witte, Otto W., Dobel, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790475/
https://www.ncbi.nlm.nih.gov/pubmed/35095737
http://dx.doi.org/10.3389/fneur.2021.793662
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author Klingner, Carsten M.
Kattlun, Fabian
Krolopp, Lena
Jochmann, Elisabeth
Volk, Gerd F.
Brodoehl, Stefan
Guntinas-Lichius, Orlando
Witte, Otto W.
Dobel, Christian
author_facet Klingner, Carsten M.
Kattlun, Fabian
Krolopp, Lena
Jochmann, Elisabeth
Volk, Gerd F.
Brodoehl, Stefan
Guntinas-Lichius, Orlando
Witte, Otto W.
Dobel, Christian
author_sort Klingner, Carsten M.
collection PubMed
description Learning from errors as the main mechanism for motor adaptation has two fundamental prerequisites: a mismatch between the intended and performed movement and the ability to adapt motor actions. Many neurological patients are limited in their ability to transfer an altered motor representation into motor action due to a compromised motor pathway. Studies that have investigated the effects of a sustained and unresolvable mismatch over multiple days found changes in brain processing that seem to optimize the potential for motor learning (increased drive for motor adaptation and a weakening of the current implementation of motor programs). However, it remains unclear whether the observed effects can be induced experimentally and more important after shorter periods. Here, we used task-based and resting-state fMRI to investigate whether the known pattern of cortical adaptations due to a sustained mismatch can be induced experimentally by a short (20 min), but unresolvable, sensory–motor mismatch by impaired facial movements in healthy participants by transient facial tapping. Similar to long-term mismatch, we found plastic changes in a network that includes the striatal, cerebellar and somatosensory brain areas. However, in contrast to long-term mismatch, we did not find the involvement of the cerebral motor cortex. The lack of the involvement of the motor cortex can be interpreted both as an effect of time and also as an effect of the lack of a reduction in the motor error. The similar effects of long-term and short-term mismatch on other parts of the sensory–motor network suggest that the brain-state caused by long-term mismatch can be (at least partly) induced by short-term mismatch. Further studies should investigate whether short-term mismatch interventions can be used as therapeutic strategy to induce an altered brain-state that increase the potential for motor learning.
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spelling pubmed-87904752022-01-27 Shaping the Sensory–Motor Network by Short-Term Unresolvable Sensory–Motor Mismatch Klingner, Carsten M. Kattlun, Fabian Krolopp, Lena Jochmann, Elisabeth Volk, Gerd F. Brodoehl, Stefan Guntinas-Lichius, Orlando Witte, Otto W. Dobel, Christian Front Neurol Neurology Learning from errors as the main mechanism for motor adaptation has two fundamental prerequisites: a mismatch between the intended and performed movement and the ability to adapt motor actions. Many neurological patients are limited in their ability to transfer an altered motor representation into motor action due to a compromised motor pathway. Studies that have investigated the effects of a sustained and unresolvable mismatch over multiple days found changes in brain processing that seem to optimize the potential for motor learning (increased drive for motor adaptation and a weakening of the current implementation of motor programs). However, it remains unclear whether the observed effects can be induced experimentally and more important after shorter periods. Here, we used task-based and resting-state fMRI to investigate whether the known pattern of cortical adaptations due to a sustained mismatch can be induced experimentally by a short (20 min), but unresolvable, sensory–motor mismatch by impaired facial movements in healthy participants by transient facial tapping. Similar to long-term mismatch, we found plastic changes in a network that includes the striatal, cerebellar and somatosensory brain areas. However, in contrast to long-term mismatch, we did not find the involvement of the cerebral motor cortex. The lack of the involvement of the motor cortex can be interpreted both as an effect of time and also as an effect of the lack of a reduction in the motor error. The similar effects of long-term and short-term mismatch on other parts of the sensory–motor network suggest that the brain-state caused by long-term mismatch can be (at least partly) induced by short-term mismatch. Further studies should investigate whether short-term mismatch interventions can be used as therapeutic strategy to induce an altered brain-state that increase the potential for motor learning. Frontiers Media S.A. 2022-01-12 /pmc/articles/PMC8790475/ /pubmed/35095737 http://dx.doi.org/10.3389/fneur.2021.793662 Text en Copyright © 2022 Klingner, Kattlun, Krolopp, Jochmann, Volk, Brodoehl, Guntinas-Lichius, Witte and Dobel. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Klingner, Carsten M.
Kattlun, Fabian
Krolopp, Lena
Jochmann, Elisabeth
Volk, Gerd F.
Brodoehl, Stefan
Guntinas-Lichius, Orlando
Witte, Otto W.
Dobel, Christian
Shaping the Sensory–Motor Network by Short-Term Unresolvable Sensory–Motor Mismatch
title Shaping the Sensory–Motor Network by Short-Term Unresolvable Sensory–Motor Mismatch
title_full Shaping the Sensory–Motor Network by Short-Term Unresolvable Sensory–Motor Mismatch
title_fullStr Shaping the Sensory–Motor Network by Short-Term Unresolvable Sensory–Motor Mismatch
title_full_unstemmed Shaping the Sensory–Motor Network by Short-Term Unresolvable Sensory–Motor Mismatch
title_short Shaping the Sensory–Motor Network by Short-Term Unresolvable Sensory–Motor Mismatch
title_sort shaping the sensory–motor network by short-term unresolvable sensory–motor mismatch
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790475/
https://www.ncbi.nlm.nih.gov/pubmed/35095737
http://dx.doi.org/10.3389/fneur.2021.793662
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