Cargando…

The Kynurenine/Tryptophan Ratio Is a Sensitive Biomarker for the Diagnosis of Pediatric Tuberculosis Among Indian Children

OBJECTIVES: Pediatric tuberculosis (TB) remains difficult to diagnose. The plasma kynurenine to tryptophan ratio (K/T ratio) is a potential biomarker for TB diagnosis and treatment response but has not been assessed in children. METHODS: We performed a targeted diagnostic accuracy analysis of four b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tornheim, Jeffrey A., Paradkar, Mandar, Zhao, Henry, Kulkarni, Vandana, Pradhan, Neeta, Kinikar, Aarti, Kagal, Anju, Gupte, Nikhil, Mave, Vidya, Gupta, Amita, Karakousis, Petros C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790563/ https://www.ncbi.nlm.nih.gov/pubmed/35095848 http://dx.doi.org/10.3389/fimmu.2021.774043

Ejemplares similares

Integration of metabolomics and transcriptomics reveals novel biomarkers in the blood for tuberculosis diagnosis in children
por: Dutta, Noton K., et al.
Publicado: (2020)

Comparative immune responses to Mycobacterium tuberculosis in people with latent infection or sterilizing protection
por: Jalbert, Emilie, et al.
Publicado: (2023)

Predictors of Mortality in Hospitalized Children with Pandemic H1N1 Influenza 2009 in Pune, India
por: Kinikar, Aarti Avinash, et al.
Publicado: (2011)

Infection free “resisters” among household contacts of adult pulmonary tuberculosis
por: Mave, Vidya, et al.
Publicado: (2019)

1397. Modern Lineages of Mycobacterium tuberculosis Were Recently Introduced in Western India and Demonstrate Increased Transmissibility
por: Dixit, Avika, et al.
Publicado: (2021)

Pediatric Tuberculosis in Young Children in India: A Prospective Study
por: Jain, Sanjay K., et al.
Publicado: (2013)

Efficacy of Six-Week Extended-Dose Nevirapine Varies by Infant Birth Weight with Greatest Relative Efficacy in Low Birth Weight Infants
por: Gupte, Nikhil, et al.
Publicado: (2016)

Maternal Syphilis: An Independent Risk Factor for Mother to Infant Human Immunodeficiency Virus Transmission
por: Kinikar, Aarti, et al.
Publicado: (2017)

Isoniazid concentrations in hair and plasma area-under-the-curve exposure among children with tuberculosis
por: Mave, Vidya, et al.
Publicado: (2017)

Maternal Colonization Versus Nosocomial Transmission as the Source of Drug-Resistant Bloodstream Infection in an Indian Neonatal Intensive Care Unit: A Prospective Cohort Study
por: Robinson, Matthew L, et al.
Publicado: (2023)

Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored
por: Thomas, Beena Elizabeth, et al.
Publicado: (2019)

Correction: Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored
por: Thomas, Beena Elizabeth, et al.
Publicado: (2019)

Tuberculin skin test and QuantiFERON-Gold In Tube assay for diagnosis of latent TB infection among household contacts of pulmonary TB patients in high TB burden setting
por: Chandrasekaran, Padmapriyadarsini, et al.
Publicado: (2018)

Utility of the Interferon-Gamma Release Assay for Latent Tuberculosis Infection Screening among Indian Health-Care Workers
por: Girish, Sunita, et al.
Publicado: (2021)

Tuberculosis preventive treatment should be considered for all household contacts of pulmonary tuberculosis patients in India
por: Paradkar, Mandar, et al.
Publicado: (2020)

Sources of household air pollution and their association with fine particulate matter in low-income urban homes in India
por: Elf, Jessica L, et al.
Publicado: (2018)

Drug-resistant Enterobacteriaceae colonization is associated with healthcare utilization and antimicrobial use among inpatients in Pune, India
por: Bharadwaj, Renu, et al.
Publicado: (2018)

Source Case Investigation for Children with TB Disease in Pune, India
por: De, Debalina, et al.
Publicado: (2014)

Impact of the Fogarty Training Program on Trainee and Institutional Research Capacity Building at a Government Medical College in India
por: Dhumal, Gauri, et al.
Publicado: (2020)

Diabetes Mellitus and Tuberculosis Treatment Outcomes in Pune, India
por: Mave, Vidya, et al.
Publicado: (2021)

Cohort for Tuberculosis Research by the Indo-US Medical Partnership (CTRIUMPH): protocol for a multicentric prospective observational study
por: Gupte, Akshay, et al.
Publicado: (2016)

Baseline IL-6 is a biomarker for unfavorable tuberculosis treatment outcomes: a multi-site discovery and validation study
por: Gupte, Akshay N., et al.
Publicado: (2022)

A Two-Gene Signature for Tuberculosis Diagnosis in Persons With Advanced HIV
por: Kulkarni, Vandana, et al.
Publicado: (2021)

Randomized Clinical Trial of High-Dose Rifampicin With or Without Levofloxacin Versus Standard of Care for Pediatric Tuberculous Meningitis: The TBM-KIDS Trial( )
por: Paradkar, Mandar S, et al.
Publicado: (2022)

Addressing knowledge gaps and prevention for tuberculosis-infected Indian adults: a vital part of elimination
por: DeLuca, Andrea, et al.
Publicado: (2018)

High risk for latent tuberculosis infection among medical residents and nursing students in India
por: Kinikar, Aarti, et al.
Publicado: (2019)

High Rates of All-cause and Gastroenteritis-related Hospitalization Morbidity and Mortality among HIV-exposed Indian Infants
por: Singh, Harjot K, et al.
Publicado: (2011)

The tryptophan–kynurenine pathway in immunomodulation and cancer metastasis
por: Basson, Charlise, et al.
Publicado: (2023)

Intensified Short Symptom Screening Program for Dengue Infection during Pregnancy, India
por: Naik, Shilpa, et al.
Publicado: (2020)

Acceptability and feasibility of a behavioral and mobile health intervention (COMBIND) shown to increase uptake of prevention of mother to child transmission (PMTCT) care in India
por: Suryavanshi, Nishi, et al.
Publicado: (2020)

Integrative Multi-Omics Reveals Serum Markers of Tuberculosis in Advanced HIV
por: Krishnan, Sonya, et al.
Publicado: (2021)

EHMTI-0189. Tryptophan-kynurenine metabolism in migraine patients
por: Majláth, Z, et al.
Publicado: (2014)

Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects
por: Badawy, Abdulla A-B
Publicado: (2017)

Tryptophan Metabolism in Rat Liver After Administration of Tryptophan, Kynurenine Metabolites, and Kynureninase Inhibitors
por: Badawy, Abdulla A.-B., et al.
Publicado: (2016)

Assessment of lung function in successfully treated tuberculosis reveals high burden of ventilatory defects and COPD
por: Gupte, Akshay N., et al.
Publicado: (2019)

Correction: Assessment of lung function in successfully treated tuberculosis reveals high burden of ventilatory defects and COPD
por: Gupte, Akshay N., et al.
Publicado: (2019)

Smokeless tobacco use and oral potentially malignant disorders among people living with HIV (PLHIV) in Pune, India: Implications for oral cancer screening in PLHIV
por: Marbaniang, Ivan, et al.
Publicado: (2022)

Mental health and quality of life among healthcare professionals during the COVID‐19 pandemic in India
por: Suryavanshi, Nishi, et al.
Publicado: (2020)

The Plasma [Kynurenine]/[Tryptophan] Ratio and Indoleamine 2,3-Dioxygenase: Time for Appraisal
por: Badawy, Abdulla A-B, et al.
Publicado: (2019)

CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation
por: Yan, Jingya, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_77gbbc1n452a848fbcjn8o2dnu