Cargando…

Thioredoxin reductase: An emerging pharmacologic target for radiosensitization of cancer

Novel agents are required to increase the radiosensitivity of cancer and improve the outcome of radiotherapy. Thioredoxin (Trx) and thioredoxin reductase (TrxR) reduce the oxidized cysteine thiols in several proteins, which regulate cellular redox, survival, proliferation, DNA synthesis, transcripti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Patwardhan, Raghavendra S., Sharma, Deepak, Sandur, Santosh K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790659/ https://www.ncbi.nlm.nih.gov/pubmed/35078017 http://dx.doi.org/10.1016/j.tranon.2022.101341

Ejemplares similares

Thioredoxin Reductase Activity Predicts Gold Nanoparticle Radiosensitization Effect
por: Penninckx, Sébastien, et al.
Publicado: (2019)

Involvement of ERK-Nrf-2 Signaling in Ionizing Radiation Induced Cell Death in Normal and Tumor Cells
por: Patwardhan, Raghavendra S., et al.
Publicado: (2013)

Effects of redox modulation by inhibition of thioredoxin reductase on radiosensitivity and gene expression
por: Selenius, Markus, et al.
Publicado: (2012)

Auranofin radiosensitizes tumor cells through targeting thioredoxin reductase and resulting overproduction of reactive oxygen species
por: Wang, Hui, et al.
Publicado: (2017)

Thioredoxin Reductase and its Inhibitors
por: Saccoccia, Fulvio, et al.
Publicado: (2014)

Acetaminophen Reactive Intermediates Target Hepatic Thioredoxin Reductase
por: Jan, Yi-Hua, et al.
Publicado: (2014)

Potent Anti-Inflammatory Activity of Ursolic Acid, a Triterpenoid Antioxidant, Is Mediated through Suppression of NF-κB, AP-1 and NF-AT
por: Checker, Rahul, et al.
Publicado: (2012)

Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer
por: Cadenas, Cristina, et al.
Publicado: (2010)

Pharmacological inhibition of thioredoxin reductase increases insulin secretion and diminishes beta cell viability
por: Brüning, Dennis, et al.
Publicado: (2021)

New drug target in protozoan parasites: the role of thioredoxin reductase
por: Andrade, Rosa M., et al.
Publicado: (2015)

The Role of Thioredoxin Reductases in Brain Development
por: Soerensen, Jonna, et al.
Publicado: (2008)

Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase
por: Prigge, Justin R., et al.
Publicado: (2017)

Metal- and Semimetal-Containing Inhibitors of Thioredoxin Reductase as Anticancer Agents
por: Gandin, Valentina, et al.
Publicado: (2015)

Expression of Thioredoxin/Thioredoxin Reductase System Genes in Aphid-Challenged Maize Seedlings
por: Sytykiewicz, Hubert, et al.
Publicado: (2020)

Identification of New Antifungal Compounds Targeting Thioredoxin Reductase of Paracoccidioides Genus
por: Abadio, Ana Karina Rodrigues, et al.
Publicado: (2015)

Acetylation Regulates Thioredoxin Reductase Oligomerization and Activity
por: Wright, David E., et al.
Publicado: (2018)

Overexpression of chloroplast NADPH-dependent thioredoxin reductase in Arabidopsis enhances leaf growth and elucidates in vivo function of reductase and thioredoxin domains
por: Toivola, Jouni, et al.
Publicado: (2013)

Characterizing Roles for the Glutathione Reductase, Thioredoxin Reductase and Thioredoxin Peroxidase-Encoding Genes of Magnaporthe oryzae during Rice Blast Disease
por: Fernandez, Jessie, et al.
Publicado: (2014)

Plasma Thioredoxin Reductase as a Potential Biomarker for Gynecologic Cancer
por: Zhu, Yinxing, et al.
Publicado: (2023)

Malabaricone C, a constituent of spice Myristica malabarica, exhibits anti-inflammatory effects via modulation of cellular redox
por: Patwardhan, Raghavendra S, et al.
Publicado: (2023)

Stress defense mechanisms of NADPH-dependent thioredoxin reductases (NTRs) in plants
por: Cha, Joon-Yung, et al.
Publicado: (2015)

Evaluation of Giardia lamblia thioredoxin reductase as drug activating enzyme and as drug target
por: Leitsch, David, et al.
Publicado: (2016)

The Cellular Thioredoxin-1/Thioredoxin Reductase-1 Driven Oxidoreduction Represents a Chemotherapeutic Target for HIV-1 Entry Inhibition
por: Reiser, Kathrin, et al.
Publicado: (2016)

Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin
por: Yang, Yijia, et al.
Publicado: (2022)

Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads
por: Kaminska, Kamila K., et al.
Publicado: (2016)

Oxidized Forms of Ergothioneine Are Substrates for Mammalian Thioredoxin Reductase
por: Jenny, Kaelyn A., et al.
Publicado: (2022)

Delivery of the selenoprotein thioredoxin reductase 1 to mammalian cells
por: Wright, David E., et al.
Publicado: (2022)

Thioredoxin Reductase Is Involved in Development and Pathogenicity in Fusarium graminearum
por: Fan, Xinyue, et al.
Publicado: (2019)

Acetylated Thioredoxin Reductase 1 Resists Oxidative Inactivation
por: Wright, David. E., et al.
Publicado: (2021)

Molecular Basis for the Interactions of Human Thioredoxins with Their Respective Reductases
por: Hossain, Md Faruq, et al.
Publicado: (2021)

Unexpected diversity of ferredoxin-dependent thioredoxin reductases in cyanobacteria
por: Buey, Rubén M, et al.
Publicado: (2021)

Plasmodium falciparum Thioredoxin Reductase (PfTrxR) and Its Role as a Target for New Antimalarial Discovery
por: McCarty, Sara E., et al.
Publicado: (2015)

Plasma activity of Thioredoxin Reductase as a Novel Biomarker in Gastric Cancer
por: Peng, Wei, et al.
Publicado: (2019)

Clinical application of thioredoxin reductase as a novel biomarker in liver cancer
por: Wu, Xuping, et al.
Publicado: (2021)

Ribonucleotide Reductase Inhibitors: A New Look at an Old Target for Radiosensitization
por: Chapman, Tobias R., et al.
Publicado: (2012)

Thioredoxin Glutathione Reductase as a Novel Drug Target: Evidence from Schistosoma japonicum
por: Song, LiJun, et al.
Publicado: (2012)

Fluorescent Probes for Mammalian Thioredoxin Reductase: Mechanistic Analysis, Construction Strategies, and Future Perspectives
por: Song, Zilong, et al.
Publicado: (2023)

Thioredoxin Reductase and Organometallic Complexes: A Pivotal System to Tackle Multidrug Resistant Tumors?
por: Salmain, Michèle, et al.
Publicado: (2023)

Targeting Thioredoxin Reductase 1 Reduction in Cancer Cells Inhibits Self-Sufficient Growth and DNA Replication
por: Yoo, Min-Hyuk, et al.
Publicado: (2007)

Preclinical Studies and Clinical Prospects of Wharton’s Jelly-Derived MSC for Treatment of Acute Radiation Syndrome
por: Bandekar, Mayuri, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_vl2n2gqcr5ui8pqjjinve120q2