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Selection of Cashmere Fineness Functional Genes by Translatomics

Cashmere fineness is an important index to evaluate cashmere quality. Liaoning Cashmere Goat (LCG) has a large cashmere production and long cashmere fiber, but its fineness is not ideal. Therefore, it is important to find genes involved in cashmere fineness that can be used in future endeavors aimin...

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Autores principales: Zhang, Yu, Zhang, Dongyun, Xu, Yanan, Qin, Yuting, Gu, Ming, Cai, Weidong, Bai, Zhixian, Zhang, Xinjiang, Chen, Rui, Sun, Yingang, Wu, Yanzhi, Wang, Zeying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790676/
https://www.ncbi.nlm.nih.gov/pubmed/35096002
http://dx.doi.org/10.3389/fgene.2021.775499
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author Zhang, Yu
Zhang, Dongyun
Xu, Yanan
Qin, Yuting
Gu, Ming
Cai, Weidong
Bai, Zhixian
Zhang, Xinjiang
Chen, Rui
Sun, Yingang
Wu, Yanzhi
Wang, Zeying
author_facet Zhang, Yu
Zhang, Dongyun
Xu, Yanan
Qin, Yuting
Gu, Ming
Cai, Weidong
Bai, Zhixian
Zhang, Xinjiang
Chen, Rui
Sun, Yingang
Wu, Yanzhi
Wang, Zeying
author_sort Zhang, Yu
collection PubMed
description Cashmere fineness is an important index to evaluate cashmere quality. Liaoning Cashmere Goat (LCG) has a large cashmere production and long cashmere fiber, but its fineness is not ideal. Therefore, it is important to find genes involved in cashmere fineness that can be used in future endeavors aiming to improve this phenotype. With the continuous advancement of research, the regulation of cashmere fineness has made new developments through high-throughput sequencing and genome-wide association analysis. It has been found that translatomics can identify genes associated with phenotypic traits. Through translatomic analysis, the skin tissue of LCG sample groups differing in cashmere fineness was sequenced by Ribo-seq. With these data, we identified 529 differentially expressed genes between the sample groups among the 27197 expressed genes. From these, 343 genes were upregulated in the fine LCG group in relation to the coarse LCG group, and 186 were downregulated in the same relationship. Through GO enrichment analysis and KEGG enrichment analysis of differential genes, the biological functions and pathways of differential genes can be found. In the GO enrichment analysis, 491 genes were significantly enriched, and the functional region was mainly in the extracellular region. In the KEGG enrichment analysis, the enrichment of the human papillomavirus infection pathway was seen the most. We found that the COL6A5 gene may affect cashmere fineness.
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spelling pubmed-87906762022-01-27 Selection of Cashmere Fineness Functional Genes by Translatomics Zhang, Yu Zhang, Dongyun Xu, Yanan Qin, Yuting Gu, Ming Cai, Weidong Bai, Zhixian Zhang, Xinjiang Chen, Rui Sun, Yingang Wu, Yanzhi Wang, Zeying Front Genet Genetics Cashmere fineness is an important index to evaluate cashmere quality. Liaoning Cashmere Goat (LCG) has a large cashmere production and long cashmere fiber, but its fineness is not ideal. Therefore, it is important to find genes involved in cashmere fineness that can be used in future endeavors aiming to improve this phenotype. With the continuous advancement of research, the regulation of cashmere fineness has made new developments through high-throughput sequencing and genome-wide association analysis. It has been found that translatomics can identify genes associated with phenotypic traits. Through translatomic analysis, the skin tissue of LCG sample groups differing in cashmere fineness was sequenced by Ribo-seq. With these data, we identified 529 differentially expressed genes between the sample groups among the 27197 expressed genes. From these, 343 genes were upregulated in the fine LCG group in relation to the coarse LCG group, and 186 were downregulated in the same relationship. Through GO enrichment analysis and KEGG enrichment analysis of differential genes, the biological functions and pathways of differential genes can be found. In the GO enrichment analysis, 491 genes were significantly enriched, and the functional region was mainly in the extracellular region. In the KEGG enrichment analysis, the enrichment of the human papillomavirus infection pathway was seen the most. We found that the COL6A5 gene may affect cashmere fineness. Frontiers Media S.A. 2022-01-04 /pmc/articles/PMC8790676/ /pubmed/35096002 http://dx.doi.org/10.3389/fgene.2021.775499 Text en Copyright © 2022 Zhang, Zhang, Xu, Qin, Gu, Cai, Bai, Zhang, Chen, Sun, Wu and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Zhang, Yu
Zhang, Dongyun
Xu, Yanan
Qin, Yuting
Gu, Ming
Cai, Weidong
Bai, Zhixian
Zhang, Xinjiang
Chen, Rui
Sun, Yingang
Wu, Yanzhi
Wang, Zeying
Selection of Cashmere Fineness Functional Genes by Translatomics
title Selection of Cashmere Fineness Functional Genes by Translatomics
title_full Selection of Cashmere Fineness Functional Genes by Translatomics
title_fullStr Selection of Cashmere Fineness Functional Genes by Translatomics
title_full_unstemmed Selection of Cashmere Fineness Functional Genes by Translatomics
title_short Selection of Cashmere Fineness Functional Genes by Translatomics
title_sort selection of cashmere fineness functional genes by translatomics
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790676/
https://www.ncbi.nlm.nih.gov/pubmed/35096002
http://dx.doi.org/10.3389/fgene.2021.775499
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