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Protocol for behavioral and neural recording during stimulation of the macaque monkey nucleus basalis

We present an experimental protocol to record neuronal activity during intermittent stimulation of nucleus basalis (NB), as macaque monkeys perform cognitive tasks. This protocol includes implantation of electrodes and generator devices to deliver electrical stimulation to NB using multiple approach...

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Detalles Bibliográficos
Autores principales: Qi, Xue-Lian, Pennington, Kendyl R., Banerjee, Christopher, Vale, Fernando L., Bick, Sarah K., Englot, Dario J., Turner, Robert S., Constantinidis, Christos, Blake, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790678/
https://www.ncbi.nlm.nih.gov/pubmed/35112086
http://dx.doi.org/10.1016/j.xpro.2022.101136
Descripción
Sumario:We present an experimental protocol to record neuronal activity during intermittent stimulation of nucleus basalis (NB), as macaque monkeys perform cognitive tasks. This protocol includes implantation of electrodes and generator devices to deliver electrical stimulation to NB using multiple approaches in monkeys. Direct stimulation of NB avoids peripheral cholinergic side effects, optimizes timing, and activates non-cholinergic projection neurons. We describe electrode preparation, surgery, and implantation for direct evaluation of how stimulation affects monkeys’ behavior and neuronal activity. For complete details on the use and execution of this profile, please refer to Qi et al. (2021).