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Oncological Outcomes After Hippocampus-Sparing Whole-Brain Radiotherapy in Cancer Patients With Newly Diagnosed Brain Oligometastases: A Single-Arm Prospective Observational Cohort Study in Taiwan

BACKGROUND: Promisingly, the technique of hippocampus sparing during WBRT (HS-WBRT) might preserve NCFs. In this research, we examined oncological outcomes, with emphasis on neurologic/non-neurologic causes of death, CNS progression, and leptomeningeal disease (LMD) recurrence in cancer patients who...

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Autores principales: Lin, Shinn-Yn, Tsan, Din-Li, Chuang, Chi-Cheng, Yang, Chi-Cheng, Pai, Ping-Ching, Wang, Chih-Liang, Wu, Yi-Ming, Lee, Cheng-Chi, Lin, Chia-Hsin, Wei, Kuo-Chen, Chou, Wen-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790705/
https://www.ncbi.nlm.nih.gov/pubmed/35096584
http://dx.doi.org/10.3389/fonc.2021.784635
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author Lin, Shinn-Yn
Tsan, Din-Li
Chuang, Chi-Cheng
Yang, Chi-Cheng
Pai, Ping-Ching
Wang, Chih-Liang
Wu, Yi-Ming
Lee, Cheng-Chi
Lin, Chia-Hsin
Wei, Kuo-Chen
Chou, Wen-Chi
author_facet Lin, Shinn-Yn
Tsan, Din-Li
Chuang, Chi-Cheng
Yang, Chi-Cheng
Pai, Ping-Ching
Wang, Chih-Liang
Wu, Yi-Ming
Lee, Cheng-Chi
Lin, Chia-Hsin
Wei, Kuo-Chen
Chou, Wen-Chi
author_sort Lin, Shinn-Yn
collection PubMed
description BACKGROUND: Promisingly, the technique of hippocampus sparing during WBRT (HS-WBRT) might preserve NCFs. In this research, we examined oncological outcomes, with emphasis on neurologic/non-neurologic causes of death, CNS progression, and leptomeningeal disease (LMD) recurrence in cancer patients who underwent HS-WBRT. METHODS: One hundred and fourteen cancer patients with newly diagnosed brain oligometastases underwent HS-WBRT were consecutively enrolled. The cumulative incidence of cancer-specific deaths (neurologic or non-neurologic), LMD recurrence, and the composite endpoint of CNS progression (CNS-CE) as the first event were computed with a competing-risks approach to characterize the oncological outcomes after HS-WBRT. RESULTS: Patients with intact brain metastases had a significantly increased likelihood of dying from non-neurologic causes of death associated with early manifestation of progressive systemic disease (hazard ratio for non-neurologic death, 1.78; 95% CI, 1.08–2.95; p = 0.025; competing-risks Fine–Gray regression), which reciprocally rendered them unlikely to encounter LMD recurrence or any pattern of CNS progression (HR for CNS-CE as the first event, 0.13; 95% CI, 0.02–0.97; p = 0.047; competing-risks Fine–Gray regression). By contrast, patients with resection cavities post-craniotomy had reciprocally increased likelihood of CNS progression which might be associated with neurologic death eventually. CONCLUSIONS: Patterns of oncological endpoints including neurologic/non-neurologic death and cumulative incidence of CNS progression manifesting as LMD recurrence are clearly clarified and contrasted between patients with intact BMs and those with resection cavities, indicating they are clinically distinct subgroups. TRIAL REGISTRATION: ClinicalTrials.gov, Identifier: NCT02504788, NCT03223675.
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spelling pubmed-87907052022-01-27 Oncological Outcomes After Hippocampus-Sparing Whole-Brain Radiotherapy in Cancer Patients With Newly Diagnosed Brain Oligometastases: A Single-Arm Prospective Observational Cohort Study in Taiwan Lin, Shinn-Yn Tsan, Din-Li Chuang, Chi-Cheng Yang, Chi-Cheng Pai, Ping-Ching Wang, Chih-Liang Wu, Yi-Ming Lee, Cheng-Chi Lin, Chia-Hsin Wei, Kuo-Chen Chou, Wen-Chi Front Oncol Oncology BACKGROUND: Promisingly, the technique of hippocampus sparing during WBRT (HS-WBRT) might preserve NCFs. In this research, we examined oncological outcomes, with emphasis on neurologic/non-neurologic causes of death, CNS progression, and leptomeningeal disease (LMD) recurrence in cancer patients who underwent HS-WBRT. METHODS: One hundred and fourteen cancer patients with newly diagnosed brain oligometastases underwent HS-WBRT were consecutively enrolled. The cumulative incidence of cancer-specific deaths (neurologic or non-neurologic), LMD recurrence, and the composite endpoint of CNS progression (CNS-CE) as the first event were computed with a competing-risks approach to characterize the oncological outcomes after HS-WBRT. RESULTS: Patients with intact brain metastases had a significantly increased likelihood of dying from non-neurologic causes of death associated with early manifestation of progressive systemic disease (hazard ratio for non-neurologic death, 1.78; 95% CI, 1.08–2.95; p = 0.025; competing-risks Fine–Gray regression), which reciprocally rendered them unlikely to encounter LMD recurrence or any pattern of CNS progression (HR for CNS-CE as the first event, 0.13; 95% CI, 0.02–0.97; p = 0.047; competing-risks Fine–Gray regression). By contrast, patients with resection cavities post-craniotomy had reciprocally increased likelihood of CNS progression which might be associated with neurologic death eventually. CONCLUSIONS: Patterns of oncological endpoints including neurologic/non-neurologic death and cumulative incidence of CNS progression manifesting as LMD recurrence are clearly clarified and contrasted between patients with intact BMs and those with resection cavities, indicating they are clinically distinct subgroups. TRIAL REGISTRATION: ClinicalTrials.gov, Identifier: NCT02504788, NCT03223675. Frontiers Media S.A. 2022-01-12 /pmc/articles/PMC8790705/ /pubmed/35096584 http://dx.doi.org/10.3389/fonc.2021.784635 Text en Copyright © 2022 Lin, Tsan, Chuang, Yang, Pai, Wang, Wu, Lee, Lin, Wei and Chou https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Lin, Shinn-Yn
Tsan, Din-Li
Chuang, Chi-Cheng
Yang, Chi-Cheng
Pai, Ping-Ching
Wang, Chih-Liang
Wu, Yi-Ming
Lee, Cheng-Chi
Lin, Chia-Hsin
Wei, Kuo-Chen
Chou, Wen-Chi
Oncological Outcomes After Hippocampus-Sparing Whole-Brain Radiotherapy in Cancer Patients With Newly Diagnosed Brain Oligometastases: A Single-Arm Prospective Observational Cohort Study in Taiwan
title Oncological Outcomes After Hippocampus-Sparing Whole-Brain Radiotherapy in Cancer Patients With Newly Diagnosed Brain Oligometastases: A Single-Arm Prospective Observational Cohort Study in Taiwan
title_full Oncological Outcomes After Hippocampus-Sparing Whole-Brain Radiotherapy in Cancer Patients With Newly Diagnosed Brain Oligometastases: A Single-Arm Prospective Observational Cohort Study in Taiwan
title_fullStr Oncological Outcomes After Hippocampus-Sparing Whole-Brain Radiotherapy in Cancer Patients With Newly Diagnosed Brain Oligometastases: A Single-Arm Prospective Observational Cohort Study in Taiwan
title_full_unstemmed Oncological Outcomes After Hippocampus-Sparing Whole-Brain Radiotherapy in Cancer Patients With Newly Diagnosed Brain Oligometastases: A Single-Arm Prospective Observational Cohort Study in Taiwan
title_short Oncological Outcomes After Hippocampus-Sparing Whole-Brain Radiotherapy in Cancer Patients With Newly Diagnosed Brain Oligometastases: A Single-Arm Prospective Observational Cohort Study in Taiwan
title_sort oncological outcomes after hippocampus-sparing whole-brain radiotherapy in cancer patients with newly diagnosed brain oligometastases: a single-arm prospective observational cohort study in taiwan
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790705/
https://www.ncbi.nlm.nih.gov/pubmed/35096584
http://dx.doi.org/10.3389/fonc.2021.784635
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