Polymer End Group Control through a Decarboxylative Cobalt-Mediated Radical Polymerization: New Avenues for Synthesizing Peptide, Protein, and Nanomaterial Conjugates

[Image: see text] Cobalt-mediated radical polymerizations (CMRPs) have been initiated by the radical decarboxylation of tetrachlorophthalimide activated esters. This allows for the controlled radical polymerization of activated monomers across a broad temperature range with a single cobalt species,...

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Autores principales: Ayurini, Meri, Chandler, Peter G., O’Leary, Paul D., Wang, Ruoxin, Rudd, David, Milewska, Karen D., Malins, Lara R., Buckle, Ashley M., Hooper, Joel F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790747/
https://www.ncbi.nlm.nih.gov/pubmed/35098233
http://dx.doi.org/10.1021/jacsau.1c00453
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author Ayurini, Meri
Chandler, Peter G.
O’Leary, Paul D.
Wang, Ruoxin
Rudd, David
Milewska, Karen D.
Malins, Lara R.
Buckle, Ashley M.
Hooper, Joel F.
author_facet Ayurini, Meri
Chandler, Peter G.
O’Leary, Paul D.
Wang, Ruoxin
Rudd, David
Milewska, Karen D.
Malins, Lara R.
Buckle, Ashley M.
Hooper, Joel F.
author_sort Ayurini, Meri
collection PubMed
description [Image: see text] Cobalt-mediated radical polymerizations (CMRPs) have been initiated by the radical decarboxylation of tetrachlorophthalimide activated esters. This allows for the controlled radical polymerization of activated monomers across a broad temperature range with a single cobalt species, with the incorporation of polymer end groups derived from simple carboxylic acid derivatives and termination with an organozinc reagent. This method has been applied to the synthesis of a polymer/graphene conjugate and a water-soluble protein/polymer conjugate, demonstrating the first examples of CMRP in graphene and protein conjugation.
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spelling pubmed-87907472022-01-27 Polymer End Group Control through a Decarboxylative Cobalt-Mediated Radical Polymerization: New Avenues for Synthesizing Peptide, Protein, and Nanomaterial Conjugates Ayurini, Meri Chandler, Peter G. O’Leary, Paul D. Wang, Ruoxin Rudd, David Milewska, Karen D. Malins, Lara R. Buckle, Ashley M. Hooper, Joel F. JACS Au [Image: see text] Cobalt-mediated radical polymerizations (CMRPs) have been initiated by the radical decarboxylation of tetrachlorophthalimide activated esters. This allows for the controlled radical polymerization of activated monomers across a broad temperature range with a single cobalt species, with the incorporation of polymer end groups derived from simple carboxylic acid derivatives and termination with an organozinc reagent. This method has been applied to the synthesis of a polymer/graphene conjugate and a water-soluble protein/polymer conjugate, demonstrating the first examples of CMRP in graphene and protein conjugation. American Chemical Society 2021-11-30 /pmc/articles/PMC8790747/ /pubmed/35098233 http://dx.doi.org/10.1021/jacsau.1c00453 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Ayurini, Meri
Chandler, Peter G.
O’Leary, Paul D.
Wang, Ruoxin
Rudd, David
Milewska, Karen D.
Malins, Lara R.
Buckle, Ashley M.
Hooper, Joel F.
Polymer End Group Control through a Decarboxylative Cobalt-Mediated Radical Polymerization: New Avenues for Synthesizing Peptide, Protein, and Nanomaterial Conjugates
title Polymer End Group Control through a Decarboxylative Cobalt-Mediated Radical Polymerization: New Avenues for Synthesizing Peptide, Protein, and Nanomaterial Conjugates
title_full Polymer End Group Control through a Decarboxylative Cobalt-Mediated Radical Polymerization: New Avenues for Synthesizing Peptide, Protein, and Nanomaterial Conjugates
title_fullStr Polymer End Group Control through a Decarboxylative Cobalt-Mediated Radical Polymerization: New Avenues for Synthesizing Peptide, Protein, and Nanomaterial Conjugates
title_full_unstemmed Polymer End Group Control through a Decarboxylative Cobalt-Mediated Radical Polymerization: New Avenues for Synthesizing Peptide, Protein, and Nanomaterial Conjugates
title_short Polymer End Group Control through a Decarboxylative Cobalt-Mediated Radical Polymerization: New Avenues for Synthesizing Peptide, Protein, and Nanomaterial Conjugates
title_sort polymer end group control through a decarboxylative cobalt-mediated radical polymerization: new avenues for synthesizing peptide, protein, and nanomaterial conjugates
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790747/
https://www.ncbi.nlm.nih.gov/pubmed/35098233
http://dx.doi.org/10.1021/jacsau.1c00453
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