Fragment Hotspot Mapping to Identify Selectivity-Determining Regions between Related Proteins

[Image: see text] Selectivity is a crucial property in small molecule development. Binding site comparisons within a protein family are a key piece of information when aiming to modulate the selectivity profile of a compound. Binding site differences can be exploited to confer selectivity for a spec...

Descripción completa

Detalles Bibliográficos
Autores principales: Smilova, Mihaela D., Curran, Peter R., Radoux, Chris J., von Delft, Frank, Cole, Jason C., Bradley, Anthony R., Marsden, Brian D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790751/
https://www.ncbi.nlm.nih.gov/pubmed/35020376
http://dx.doi.org/10.1021/acs.jcim.1c00823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790751/
https://www.ncbi.nlm.nih.gov/pubmed/35020376
http://dx.doi.org/10.1021/acs.jcim.1c00823

Ejemplares similares