Cargando…

Inhibition of Microtubule Dynamics in Cancer Cells by Indole-Modified Latonduine Derivatives and Their Metal Complexes

[Image: see text] Indolo[2,3-d]benzazepines (indololatonduines) are rarely discussed in the literature. In this project, we prepared a series of novel indololatonduine derivatives and their Ru(II) and Os(II) complexes and investigated their microtubule-targeting properties in comparison with paclita...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wittmann, Christopher, Sivchenko, Anastasiia S., Bacher, Felix, Tong, Kelvin K. H., Guru, Navjot, Wilson, Thomas, Gonzales, Junior, Rauch, Hartmut, Kossatz, Susanne, Reiner, Thomas, Babak, Maria V., Arion, Vladimir B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790753/ https://www.ncbi.nlm.nih.gov/pubmed/34995063 http://dx.doi.org/10.1021/acs.inorgchem.1c03154

Ejemplares similares

Highly Antiproliferative Latonduine and Indolo[2,3-c]quinoline Derivatives: Complex Formation with Copper(II) Markedly Changes the Kinase Inhibitory Profile
por: Wittmann, Christopher, et al.
Publicado: (2022)

Combination of Selective PARP3 and PARP16 Inhibitory Analogues of Latonduine A Corrects F508del-CFTR Trafficking
por: Centko, Ryan M., et al.
Publicado: (2020)

Fluorescence-guided resection of tumors in mouse models of oral cancer
por: Demétrio de Souza França, Paula, et al.
Publicado: (2020)

An (89)Zr-HDL PET Tracer Monitors Response to a CSF1R Inhibitor
por: Mason, Christian A., et al.
Publicado: (2020)

Detection and Delineation of Oral Cancer With a PARP1-Targeted Optical Imaging Agent
por: Kossatz, Susanne, et al.
Publicado: (2017)

Optical Imaging of PARP1 in Response to Radiation in Oral Squamous Cell Carcinoma
por: Kossatz, Susanne, et al.
Publicado: (2016)

Ready access to 7,8-dihydroindolo[2,3-d][1]benzazepine-6(5H)-one scaffold and analogues via early-stage Fischer ring-closure reaction
por: Kuznetcova, Irina, et al.
Publicado: (2022)

Fluorescence labeling of a Na(V)1.7-targeted peptide for near-infrared nerve visualization
por: Gonzales, Junior, et al.
Publicado: (2020)

Indolo[2,3-e]benzazocines and indolo[2,3-f]benzazonines and their copper(ii) complexes as microtubule destabilizing agents
por: Wittmann, Christopher, et al.
Publicado: (2023)

Elucidation of Structure–Activity Relationships in Indolobenzazepine-Derived Ligands and Their Copper(II) Complexes: the Role of Key Structural Components and Insight into the Mechanism of Action
por: Kuznetcova, Irina, et al.
Publicado: (2022)

Current Practice and Emerging Molecular Imaging Technologies in Oral Cancer Screening
por: Strome, Arianna, et al.
Publicado: (2018)

[(18)F]PARPi Imaging Is Not Affected by HPV Status In Vitro
por: Guru, Navjot, et al.
Publicado: (2021)

EBs clip CLIPs to growing microtubule ends
por: Wittmann, Torsten
Publicado: (2008)

GSK3β phosphorylation modulates CLASP–microtubule association and lamella microtubule attachment
por: Kumar, Praveen, et al.
Publicado: (2009)

Ruthenium− and Osmium−Arene Complexes of 2-Substituted Indolo[3,2-c]quinolines: Synthesis, Structure, Spectroscopic Properties, and Antiproliferative Activity
por: Filak, Lukas K., et al.
Publicado: (2010)

Radioiodinated PARP1 tracers for glioblastoma imaging
por: Salinas, Beatriz, et al.
Publicado: (2015)

Microtubule dynamics regulation contributes to endothelial morphogenesis
por: Lyle, Karen S., et al.
Publicado: (2012)

Targeting and transport: How microtubules control focal adhesion dynamics
por: Stehbens, Samantha, et al.
Publicado: (2012)

Detection and delineation of oral cancer with a PARP1 targeted optical imaging agent
por: Kossatz, Susanne, et al.
Publicado: (2016)

Centrioles without microtubules: a new morphological type of centriole
por: Uzbekov, Rustem, et al.
Publicado: (2018)

Precedence for the Role of Indole with Pathogens
por: Wood, Thomas K., et al.
Publicado: (2019)

Diprenylated Indole Alkaloids from Fruits of Hexalobus monopetalus
por: Malebo, Hamisi M., et al.
Publicado: (2014)

The Spicy Story of Cannabimimetic Indoles
por: Howlett, Allyn C., et al.
Publicado: (2021)

Spastin's Microtubule-Binding Properties and Comparison to Katanin
por: Eckert, Thomas, et al.
Publicado: (2012)

Regulation of leading edge microtubule and actin dynamics downstream of Rac1
por: Wittmann, Torsten, et al.
Publicado: (2003)

Combatting Persister Cells With Substituted Indoles
por: Song, Sooyeon, et al.
Publicado: (2020)

Stimulation of microtubule-based transport by nucleation of microtubules on pigment granules
por: Semenova, Irina, et al.
Publicado: (2017)

The mitotic spindle protein CKAP2 potently increases formation and stability of microtubules
por: McAlear, Thomas S, et al.
Publicado: (2022)

Effects of microtubule length and crowding on active microtubule network organization
por: Chew, Wei-Xiang, et al.
Publicado: (2023)

N‐Trifluoromethyl Hydrazines, Indoles and Their Derivatives
por: Bouayad‐Gervais, Samir, et al.
Publicado: (2020)

It’s Time to Shift the Paradigm: Translation and Clinical Application of Non-αvβ3 Integrin Targeting Radiopharmaceuticals
por: Kossatz, Susanne, et al.
Publicado: (2021)

Discriminating radiation injury from recurrent tumor with [(18)F]PARPi and amino acid PET in mouse models
por: Donabedian, Patrick L., et al.
Publicado: (2018)

Advancements in PARP1 Targeted Nuclear Imaging and Theranostic Probes
por: Ambur Sankaranarayanan, Ramya, et al.
Publicado: (2020)

Microtubule binding by dynactin is required for microtubule organization but not cargo transport
por: Kim, Hwajin, et al.
Publicado: (2007)

Physiological Response of Corynebacterium glutamicum to Indole
por: Walter, Tatjana, et al.
Publicado: (2020)

RGD-Binding Integrins Revisited: How Recently Discovered Functions and Novel Synthetic Ligands (Re-)Shape an Ever-Evolving Field
por: Ludwig, Beatrice S., et al.
Publicado: (2021)

DNA Repair Enzyme Poly(ADP-Ribose) Polymerase 1/2 (PARP1/2)-Targeted Nuclear Imaging and Radiotherapy
por: Nguyen, Nghia T., et al.
Publicado: (2022)

Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3β in migrating epithelial cells
por: Wittmann, Torsten, et al.
Publicado: (2005)

LIS1 and DCX: Implications for Brain Development and Human Disease in Relation to Microtubules
por: Reiner, Orly
Publicado: (2013)

Microtubules born on microtubules
por: LeBrasseur, Nicole
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_72mg69suvaifcpnvpa8qd37ka0