Cargando…

3-D Stochastic Numerical Breast Phantoms for Enabling Virtual Imaging Trials of Ultrasound Computed Tomography

Ultrasound computed tomography (USCT) is an emerging imaging modality for breast imaging that can produce quantitative images that depict the acoustic properties of tissues. Computer-simulation studies, also known as virtual imaging trials, provide researchers with an economical and convenient route...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Fu, Villa, Umberto, Park, Seonyeong, Anastasio, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790767/
https://www.ncbi.nlm.nih.gov/pubmed/34520354
http://dx.doi.org/10.1109/TUFFC.2021.3112544
_version_ 1784640087900815360
author Li, Fu
Villa, Umberto
Park, Seonyeong
Anastasio, Mark A.
author_facet Li, Fu
Villa, Umberto
Park, Seonyeong
Anastasio, Mark A.
author_sort Li, Fu
collection PubMed
description Ultrasound computed tomography (USCT) is an emerging imaging modality for breast imaging that can produce quantitative images that depict the acoustic properties of tissues. Computer-simulation studies, also known as virtual imaging trials, provide researchers with an economical and convenient route to systematically explore imaging system designs and image reconstruction methods. When simulating an imaging technology intended for clinical use, it is essential to employ realistic numerical phantoms that can facilitate the objective, or task-based, assessment of image quality (IQ). Moreover, when computing objective IQ measures, an ensemble of such phantoms should be employed, which displays the variability in anatomy and object properties that are representative of the to-be-imaged patient cohort. Such stochastic phantoms for clinically relevant applications of USCT are currently lacking. In this work, a methodology for producing realistic 3-D numerical breast phantoms for enabling clinically relevant computer-simulationstudies of USCT breast imaging is presented. By extending and adapting an existing stochastic 3-D breast phantom for use with USCT, methods for creating ensembles of numerical acoustic breast phantoms are established. These breast phantoms will possess clinically relevant variations in breast size, composition, acoustic properties, tumor locations, and tissue textures. To demonstrate the use of the phantoms in virtual USCT studies, two brief case studies are presented, which addresses the development and assessment of image reconstruction procedures. Examples of breast phantoms produced by use of the proposed methods and a collection of 52 sets of simulated USCT measurement data have been made open source for use in image reconstruction development.
format Online
Article
Text
id pubmed-8790767
institution National Center for Biotechnology Information
language English
publishDate 2022
record_format MEDLINE/PubMed
spelling pubmed-87907672022-01-26 3-D Stochastic Numerical Breast Phantoms for Enabling Virtual Imaging Trials of Ultrasound Computed Tomography Li, Fu Villa, Umberto Park, Seonyeong Anastasio, Mark A. IEEE Trans Ultrason Ferroelectr Freq Control Article Ultrasound computed tomography (USCT) is an emerging imaging modality for breast imaging that can produce quantitative images that depict the acoustic properties of tissues. Computer-simulation studies, also known as virtual imaging trials, provide researchers with an economical and convenient route to systematically explore imaging system designs and image reconstruction methods. When simulating an imaging technology intended for clinical use, it is essential to employ realistic numerical phantoms that can facilitate the objective, or task-based, assessment of image quality (IQ). Moreover, when computing objective IQ measures, an ensemble of such phantoms should be employed, which displays the variability in anatomy and object properties that are representative of the to-be-imaged patient cohort. Such stochastic phantoms for clinically relevant applications of USCT are currently lacking. In this work, a methodology for producing realistic 3-D numerical breast phantoms for enabling clinically relevant computer-simulationstudies of USCT breast imaging is presented. By extending and adapting an existing stochastic 3-D breast phantom for use with USCT, methods for creating ensembles of numerical acoustic breast phantoms are established. These breast phantoms will possess clinically relevant variations in breast size, composition, acoustic properties, tumor locations, and tissue textures. To demonstrate the use of the phantoms in virtual USCT studies, two brief case studies are presented, which addresses the development and assessment of image reconstruction procedures. Examples of breast phantoms produced by use of the proposed methods and a collection of 52 sets of simulated USCT measurement data have been made open source for use in image reconstruction development. 2022-01 2021-12-31 /pmc/articles/PMC8790767/ /pubmed/34520354 http://dx.doi.org/10.1109/TUFFC.2021.3112544 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see https://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Li, Fu
Villa, Umberto
Park, Seonyeong
Anastasio, Mark A.
3-D Stochastic Numerical Breast Phantoms for Enabling Virtual Imaging Trials of Ultrasound Computed Tomography
title 3-D Stochastic Numerical Breast Phantoms for Enabling Virtual Imaging Trials of Ultrasound Computed Tomography
title_full 3-D Stochastic Numerical Breast Phantoms for Enabling Virtual Imaging Trials of Ultrasound Computed Tomography
title_fullStr 3-D Stochastic Numerical Breast Phantoms for Enabling Virtual Imaging Trials of Ultrasound Computed Tomography
title_full_unstemmed 3-D Stochastic Numerical Breast Phantoms for Enabling Virtual Imaging Trials of Ultrasound Computed Tomography
title_short 3-D Stochastic Numerical Breast Phantoms for Enabling Virtual Imaging Trials of Ultrasound Computed Tomography
title_sort 3-d stochastic numerical breast phantoms for enabling virtual imaging trials of ultrasound computed tomography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790767/
https://www.ncbi.nlm.nih.gov/pubmed/34520354
http://dx.doi.org/10.1109/TUFFC.2021.3112544
work_keys_str_mv AT lifu 3dstochasticnumericalbreastphantomsforenablingvirtualimagingtrialsofultrasoundcomputedtomography
AT villaumberto 3dstochasticnumericalbreastphantomsforenablingvirtualimagingtrialsofultrasoundcomputedtomography
AT parkseonyeong 3dstochasticnumericalbreastphantomsforenablingvirtualimagingtrialsofultrasoundcomputedtomography
AT anastasiomarka 3dstochasticnumericalbreastphantomsforenablingvirtualimagingtrialsofultrasoundcomputedtomography