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Recent advances of cancer chemodynamic therapy based on Fenton/Fenton-like chemistry

Applying Fenton chemistry in the tumor microenvironment (TME) for cancer therapy is the most significant feature of chemodynamic therapy (CDT). Owing to the mild acid and overexpressed H(2)O(2) in TME, more cytotoxic hydroxyl radicals (˙OH) are generated in tumor cells via Fenton and Fenton-like rea...

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Autores principales: Cao, Changyu, Wang, Xiaorui, Yang, Nan, Song, Xuejiao, Dong, Xiaochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790788/
https://www.ncbi.nlm.nih.gov/pubmed/35211255
http://dx.doi.org/10.1039/d1sc05482a
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author Cao, Changyu
Wang, Xiaorui
Yang, Nan
Song, Xuejiao
Dong, Xiaochen
author_facet Cao, Changyu
Wang, Xiaorui
Yang, Nan
Song, Xuejiao
Dong, Xiaochen
author_sort Cao, Changyu
collection PubMed
description Applying Fenton chemistry in the tumor microenvironment (TME) for cancer therapy is the most significant feature of chemodynamic therapy (CDT). Owing to the mild acid and overexpressed H(2)O(2) in TME, more cytotoxic hydroxyl radicals (˙OH) are generated in tumor cells via Fenton and Fenton-like reactions. Without external stimulus and drug resistance generation, reactive oxygen species (ROS)-mediated CDT exhibits a specific and desirable anticancer effect and has been seen as a promising strategy for cancer therapy. However, optimizing the treatment efficiency of CDT in TME is still challenging because of the limited catalytic efficiency of CDT agents and the strong cancer antioxidant capacity in TME. Hence, scientists are trying their best to design and fabricate many more CDT agents with excellent catalytic activity and remodeling TME for optimal CDT. In this perspective, the latest progress of CDT is discussed, with some representative examples presented. Consequently, promising strategies for further optimizing the efficiency of CDT guided by Fenton chemistry are provided. Most importantly, several feasible ways of developing CDT in the future are offered for reference.
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spelling pubmed-87907882022-02-23 Recent advances of cancer chemodynamic therapy based on Fenton/Fenton-like chemistry Cao, Changyu Wang, Xiaorui Yang, Nan Song, Xuejiao Dong, Xiaochen Chem Sci Chemistry Applying Fenton chemistry in the tumor microenvironment (TME) for cancer therapy is the most significant feature of chemodynamic therapy (CDT). Owing to the mild acid and overexpressed H(2)O(2) in TME, more cytotoxic hydroxyl radicals (˙OH) are generated in tumor cells via Fenton and Fenton-like reactions. Without external stimulus and drug resistance generation, reactive oxygen species (ROS)-mediated CDT exhibits a specific and desirable anticancer effect and has been seen as a promising strategy for cancer therapy. However, optimizing the treatment efficiency of CDT in TME is still challenging because of the limited catalytic efficiency of CDT agents and the strong cancer antioxidant capacity in TME. Hence, scientists are trying their best to design and fabricate many more CDT agents with excellent catalytic activity and remodeling TME for optimal CDT. In this perspective, the latest progress of CDT is discussed, with some representative examples presented. Consequently, promising strategies for further optimizing the efficiency of CDT guided by Fenton chemistry are provided. Most importantly, several feasible ways of developing CDT in the future are offered for reference. The Royal Society of Chemistry 2021-11-29 /pmc/articles/PMC8790788/ /pubmed/35211255 http://dx.doi.org/10.1039/d1sc05482a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Cao, Changyu
Wang, Xiaorui
Yang, Nan
Song, Xuejiao
Dong, Xiaochen
Recent advances of cancer chemodynamic therapy based on Fenton/Fenton-like chemistry
title Recent advances of cancer chemodynamic therapy based on Fenton/Fenton-like chemistry
title_full Recent advances of cancer chemodynamic therapy based on Fenton/Fenton-like chemistry
title_fullStr Recent advances of cancer chemodynamic therapy based on Fenton/Fenton-like chemistry
title_full_unstemmed Recent advances of cancer chemodynamic therapy based on Fenton/Fenton-like chemistry
title_short Recent advances of cancer chemodynamic therapy based on Fenton/Fenton-like chemistry
title_sort recent advances of cancer chemodynamic therapy based on fenton/fenton-like chemistry
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8790788/
https://www.ncbi.nlm.nih.gov/pubmed/35211255
http://dx.doi.org/10.1039/d1sc05482a
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