Effect of Naloxegol on Opioid-Induced Esophageal Motility Disorder

Opioid effects on lower gastrointestinal motility are well documented, and increasing attention is being paid to their effect on esophageal motility. Naloxegol is a µ-opioid receptor antagonist that is used for opioid-induced constipation, but its impact on esophageal motility has not been well docu...

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Autores principales: Ulteig, Crista, Ciezki, Kristin, Jacobson, Megan, Singh, Maharaj, Sharma, Tarun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791044/
https://www.ncbi.nlm.nih.gov/pubmed/35097149
http://dx.doi.org/10.14309/crj.0000000000000723
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author Ulteig, Crista
Ciezki, Kristin
Jacobson, Megan
Singh, Maharaj
Sharma, Tarun
author_facet Ulteig, Crista
Ciezki, Kristin
Jacobson, Megan
Singh, Maharaj
Sharma, Tarun
author_sort Ulteig, Crista
collection PubMed
description Opioid effects on lower gastrointestinal motility are well documented, and increasing attention is being paid to their effect on esophageal motility. Naloxegol is a µ-opioid receptor antagonist that is used for opioid-induced constipation, but its impact on esophageal motility has not been well documented. We report a case series of 3 patients with coexisting esophageal dysmotility and constipation on chronic opioids that improved both symptoms after starting naloxegol. Based on these observational studies, we propose that formal studies be conducted to assess the effect of naloxegol on opioid-induced esophageal dysmotility.
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spelling pubmed-87910442022-01-27 Effect of Naloxegol on Opioid-Induced Esophageal Motility Disorder Ulteig, Crista Ciezki, Kristin Jacobson, Megan Singh, Maharaj Sharma, Tarun ACG Case Rep J Case Report Opioid effects on lower gastrointestinal motility are well documented, and increasing attention is being paid to their effect on esophageal motility. Naloxegol is a µ-opioid receptor antagonist that is used for opioid-induced constipation, but its impact on esophageal motility has not been well documented. We report a case series of 3 patients with coexisting esophageal dysmotility and constipation on chronic opioids that improved both symptoms after starting naloxegol. Based on these observational studies, we propose that formal studies be conducted to assess the effect of naloxegol on opioid-induced esophageal dysmotility. Wolters Kluwer 2022-01-25 /pmc/articles/PMC8791044/ /pubmed/35097149 http://dx.doi.org/10.14309/crj.0000000000000723 Text en © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Ulteig, Crista
Ciezki, Kristin
Jacobson, Megan
Singh, Maharaj
Sharma, Tarun
Effect of Naloxegol on Opioid-Induced Esophageal Motility Disorder
title Effect of Naloxegol on Opioid-Induced Esophageal Motility Disorder
title_full Effect of Naloxegol on Opioid-Induced Esophageal Motility Disorder
title_fullStr Effect of Naloxegol on Opioid-Induced Esophageal Motility Disorder
title_full_unstemmed Effect of Naloxegol on Opioid-Induced Esophageal Motility Disorder
title_short Effect of Naloxegol on Opioid-Induced Esophageal Motility Disorder
title_sort effect of naloxegol on opioid-induced esophageal motility disorder
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791044/
https://www.ncbi.nlm.nih.gov/pubmed/35097149
http://dx.doi.org/10.14309/crj.0000000000000723
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