Hidden RNA pairings counteract the “first-come, first-served” splicing principle to drive stochastic choice in Dscam1 splice variants

Drosophila melanogaster Dscam1 encodes 38,016 isoforms via mutually exclusive splicing; however, the regulatory mechanism behind this is not fully understood. Here, we found a set of hidden RNA secondary structures that balance the stochastic choice of Dscam1 splice variants (designated balancer RNA...

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Detalles Bibliográficos
Autores principales: Dong, Haiyang, Xu, Bingbing, Guo, Pengjuan, Zhang, Jian, Yang, Xi, Li, Lei, Fu, Ying, Shi, Jilong, Zhang, Shixin, Zhu, Yanda, Shi, Yang, Zhou, Fengyan, Bian, Lina, You, Wendong, Shi, Feng, Yang, Xiaofeng, Huang, Jianhua, He, Haihuai, Jin, Yongfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791459/
https://www.ncbi.nlm.nih.gov/pubmed/35080968
http://dx.doi.org/10.1126/sciadv.abm1763

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