Identification of shared tumor epitopes from endogenous retroviruses inducing high-avidity cytotoxic T cells for cancer immunotherapy

Human endogenous retroviruses (HERVs) represent 8% of the human genome. HERV products may represent tumor antigens relevant for cancer immunotherapy. We developed a bioinformatic approach to identify shared CD8(+) T cell epitopes derived from cancer-associated HERVs in solid tumors. Six candidates a...

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Detalles Bibliográficos
Autores principales: Bonaventura, Paola, Alcazer, Vincent, Mutez, Virginie, Tonon, Laurie, Martin, Juliette, Chuvin, Nicolas, Michel, Emilie, Boulos, Rasha E., Estornes, Yann, Valladeau-Guilemond, Jenny, Viari, Alain, Wang, Qing, Caux, Christophe, Depil, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791462/
https://www.ncbi.nlm.nih.gov/pubmed/35080970
http://dx.doi.org/10.1126/sciadv.abj3671

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