Cargando…
Therapeutic treatment with the anti-inflammatory drug candidate MW151 may partially reduce memory impairment and normalizes hippocampal metabolic markers in a mouse model of comorbid amyloid and vascular pathology
Alzheimer’s disease (AD) is the leading cause of dementia in the elderly, but therapeutic options are lacking. Despite long being able to effectively treat the ill-effects of pathology present in various rodent models of AD, translation of these strategies to the clinic has so far been disappointing...
Autores principales: | Braun, David J., Powell, David K., McLouth, Christopher J., Roy, Saktimayee M., Watterson, D. Martin, Van Eldik, Linda J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791470/ https://www.ncbi.nlm.nih.gov/pubmed/35081152 http://dx.doi.org/10.1371/journal.pone.0262474 |
Ejemplares similares
-
MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses
por: Bachstetter, Adam D., et al.
Publicado: (2016) -
First‐in‐Human Studies of MW01‐6‐189WH, a Brain‐Penetrant, Antineuroinflammatory Small‐Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers
por: Van Eldik, Linda J., et al.
Publicado: (2020) -
Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes
por: Zhou, Zhengqiu, et al.
Publicado: (2017) -
A Selective and
Brain Penetrant p38αMAPK Inhibitor
Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates
Neuroinflammation and Cognitive Dysfunction
por: Roy, Saktimayee M., et al.
Publicado: (2019) -
Correction to “A
Selective and Brain Penetrant
p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric
Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction”
por: Roy, Saktimayee M., et al.
Publicado: (2020)