Using population-specific add-on polymorphisms to improve genotype imputation in underrepresented populations

Genome-wide association studies rely on the statistical inference of untyped variants, called imputation, to increase the coverage of genotyping arrays. However, the results are often suboptimal in populations underrepresented in existing reference panels and array designs, since the selected single...

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Detalles Bibliográficos
Autores principales: Xu, Zhi Ming, Rüeger, Sina, Zwyer, Michaela, Brites, Daniela, Hiza, Hellen, Reinhard, Miriam, Rutaihwa, Liliana, Borrell, Sonia, Isihaka, Faima, Temba, Hosiana, Maroa, Thomas, Naftari, Rastard, Hella, Jerry, Sasamalo, Mohamed, Reither, Klaus, Portevin, Damien, Gagneux, Sebastien, Fellay, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791479/
https://www.ncbi.nlm.nih.gov/pubmed/35025869
http://dx.doi.org/10.1371/journal.pcbi.1009628

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