Single-cell sequencing demonstrates complex resistance landscape in CLL and MCL treated with BTK and BCL2 inhibitors

The genomic landscape of resistance to targeted agents (TAs) used as monotherapy in chronic lymphocytic leukemia (CLL) is complex and often heterogeneous at the patient level. To gain insight into the clonal architecture of acquired genomic resistance to Bruton tyrosine kinase (BTK) inhibitors and B...

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Detalles Bibliográficos
Autores principales: Thompson, Ella R., Nguyen, Tamia, Kankanige, Yamuna, Markham, John F., Anderson, Mary Ann, Handunnetti, Sasanka M., Thijssen, Rachel, Yeh, Paul Sung-Hao, Tam, Constantine S., Seymour, John F., Roberts, Andrew W., Westerman, David A., Blombery, Piers
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Stimulus Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791563/
https://www.ncbi.nlm.nih.gov/pubmed/34861696
http://dx.doi.org/10.1182/bloodadvances.2021006211

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