Laminin G1 residues of protein S mediate its TFPI cofactor function and are competitively regulated by C4BP

Protein S is a cofactor in the tissue factor pathway inhibitor (TFPI) anticoagulant pathway. It enhances TFPIα-mediated inhibition of factor (F)Xa activity and generation. The enhancement is dependent on a TFPIα-protein S interaction involving TFPIα Kunitz 3 and protein S laminin G-type (LG)-1. C4b...

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Detalles Bibliográficos
Autores principales: Teraz-Orosz, Adrienn, Gierula, Magdalena, Petri, Anastasis, Jones, David, Keniyopoullos, Renos, Folgado, Patricia Badia, Santamaria, Salvatore, Crawley, James T. B., Lane, David A., Ahnström, Josefin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791571/
https://www.ncbi.nlm.nih.gov/pubmed/34731882
http://dx.doi.org/10.1182/bloodadvances.2021005382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791571/
https://www.ncbi.nlm.nih.gov/pubmed/34731882
http://dx.doi.org/10.1182/bloodadvances.2021005382

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