Skin and heart allograft rejection solely by long-lived alloreactive T(RM) cells in skin of severe combined immunodeficient mice

Whether induced tissue-resident memory T (T(RM)) cells in nonlymphoid organs alone can mediate allograft rejection is unknown. By grafting alloskin or heart into severe combined immunodeficient or Rag2KO mice in which a piece of induced CD4(+) and/or CD8(+) T(RM) cell–containing MHC-matched or synge...

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Detalles Bibliográficos
Autores principales: Tian, Qianchuan, Zhang, Zhaoqi, Tan, Liang, Yang, Fan, Xu, Yanan, Guo, Yinan, Wei, Dong, Wu, Changhong, Cao, Peng, Ji, Jiawei, Wang, Wei, Xie, Xubiao, Zhao, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791614/
https://www.ncbi.nlm.nih.gov/pubmed/35080985
http://dx.doi.org/10.1126/sciadv.abk0270

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