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Enhancing CDK4/6 inhibitor therapy for medulloblastoma using nanoparticle delivery and scRNA-seq–guided combination with sapanisertib

The therapeutic potential of CDK4/6 inhibitors for brain tumors has been limited by recurrence. To address recurrence, we tested a nanoparticle formulation of CDK4/6 inhibitor palbociclib (POx-Palbo) in mice genetically-engineered to develop SHH-driven medulloblastoma, alone or in combination with s...

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Detalles Bibliográficos
Autores principales:	Lim, Chaemin, Dismuke, Taylor, Malawsky, Daniel, Ramsey, Jacob D., Hwang, Duhyeong, Godfrey, Virginia L., Kabanov, Alexander V., Gershon, Timothy R., Sokolsky-Papkov, Marina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791615/ https://www.ncbi.nlm.nih.gov/pubmed/35080986 http://dx.doi.org/10.1126/sciadv.abl5838

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