The transmembrane endoplasmic reticulum–associated E3 ubiquitin ligase TRIM13 restrains the pathogenic-DNA–triggered inflammatory response

The endoplasmic reticulum (ER)–localized stimulator of interferon genes (STING) is the core adaptor for the pathogenic-DNA–triggered innate response. Aberrant activation of STING causes autoinflammatory and autoimmune diseases, raising the concern about how STING is finely tuned during innate respon...

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Detalles Bibliográficos
Autores principales: Li, Xuelian, Yu, Zhou, Fang, Qian, Yang, Mingjin, Huang, Jiaying, Li, Zheng, Wang, Jianli, Chen, Taoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791621/
https://www.ncbi.nlm.nih.gov/pubmed/35080984
http://dx.doi.org/10.1126/sciadv.abh0496

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