Proteinuria is accompanied by intratubular complement activation and apical membrane deposition of C3dg and C5b-9 in kidney transplant recipients

Proteinuria predicts accelerated decline in kidney function in kidney transplant recipients (KTRs). We hypothesized that aberrant filtration of complement factors causes intraluminal activation, apical membrane attack on tubular cells, and progressive injury. Biobanked samples from two previous stud...

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Detalles Bibliográficos
Autores principales: Isaksson, Gustaf L., Nielsen, Marie B., Hinrichs, Gitte R., Krogstrup, Nicoline V., Zachar, Rikke, Stubmark, Heidi, Svenningsen, Per, Madsen, Kirsten, Bistrup, Claus, Jespersen, Bente, Birn, Henrik, Palarasah, Yaseelan, Jensen, Boye L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791842/
https://www.ncbi.nlm.nih.gov/pubmed/34927448
http://dx.doi.org/10.1152/ajprenal.00300.2021

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