Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1

Mechanical overload of the vascular wall is a pathological hallmark of life-threatening abdominal aortic aneurysms (AAA). However, how this mechanical stress resonates at the unicellular level of vascular smooth muscle cells (VSMC) is undefined. Here we show defective mechano-phenotype signatures of...

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Detalles Bibliográficos
Autores principales: Qian, Weiyi, Hadi, Tarik, Silvestro, Michele, Ma, Xiao, Rivera, Cristobal F., Bajpai, Apratim, Li, Rui, Zhang, Zijing, Qu, Hengdong, Tellaoui, Rayan Sleiman, Corsica, Annanina, Zias, Ariadne L., Garg, Karan, Maldonado, Thomas, Ramkhelawon, Bhama, Chen, Weiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8791986/
https://www.ncbi.nlm.nih.gov/pubmed/35082286
http://dx.doi.org/10.1038/s41467-021-27874-5

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