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Bupivacaine reduces GlyT1 expression by potentiating the p-AMPKα/BDNF signalling pathway in spinal astrocytes of rats

Bupivacaine, a local anaesthetic, is widely applied in the epidural or subarachnoid space to clinically manage acute and chronic pain. However, the underlying mechanisms are complex and unclear. Glycine transporter 1 (GlyT1) in the spinal cord plays a critical role in various pathologic pain conditi...

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Detalles Bibliográficos
Autores principales:	Lu, Kaimei, Zhao, Liyan, Zhang, Yonghai, Yang, Fan, Zhang, Huiwen, Wang, Jie, Li, Bin, Ji, Guimei, Yu, Jianqiang, Ma, Hanxiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792009/ https://www.ncbi.nlm.nih.gov/pubmed/35082359 http://dx.doi.org/10.1038/s41598-022-05478-3

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