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New Trends and Evidence for the Management of Renal Angiomyolipoma: A Comprehensive Narrative Review of the Literature

Treatment of renal angiomyolipoma (AML) seeks to reduce related complications and preserve kidney function. The purpose of this article was to perform an updated literature review on the diagnosis, therapeutic options, and criteria for invasive intervention in patients with renal AML. Computerized t...

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Autores principales: Restrepo, Juan Camilo Álvarez, Millan, David Andres Castañeda, Sabogal, Carlos Andres Riveros, Bernal, Andres Felipe Puentes, Donoso, Wilfredo Donoso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Codon Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792032/
https://www.ncbi.nlm.nih.gov/pubmed/35096516
http://dx.doi.org/10.15586/jkcvhl.v9i1.177
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author Restrepo, Juan Camilo Álvarez
Millan, David Andres Castañeda
Sabogal, Carlos Andres Riveros
Bernal, Andres Felipe Puentes
Donoso, Wilfredo Donoso
author_facet Restrepo, Juan Camilo Álvarez
Millan, David Andres Castañeda
Sabogal, Carlos Andres Riveros
Bernal, Andres Felipe Puentes
Donoso, Wilfredo Donoso
author_sort Restrepo, Juan Camilo Álvarez
collection PubMed
description Treatment of renal angiomyolipoma (AML) seeks to reduce related complications and preserve kidney function. The purpose of this article was to perform an updated literature review on the diagnosis, therapeutic options, and criteria for invasive intervention in patients with renal AML. Computerized tomography is the standard diagnostic method for renal AML, while definitive diagnosis is made by histopathology. The management of choice in most cases is active surveillance (AS), with a clinical and imaging follow-up protocol. In high-risk cases, therapeutic management should be considered, with alternatives such as selective arterial embolization (SAE), nephron-sparing surgery (NSS), and mTOR inhibitors in selected patients. Renal AML in women of childbearing age, those with growth >0.25 cm/year, intralesional aneurysms >5 mm, and clinically significant symptoms may qualify for active treatment. Despite the limitations derived from the available evidence, it is possible to consider SAE, NSS, and the use of mTOR inhibitors as management alternatives for selected patients.
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spelling pubmed-87920322022-01-28 New Trends and Evidence for the Management of Renal Angiomyolipoma: A Comprehensive Narrative Review of the Literature Restrepo, Juan Camilo Álvarez Millan, David Andres Castañeda Sabogal, Carlos Andres Riveros Bernal, Andres Felipe Puentes Donoso, Wilfredo Donoso J Kidney Cancer VHL Narrative Review Treatment of renal angiomyolipoma (AML) seeks to reduce related complications and preserve kidney function. The purpose of this article was to perform an updated literature review on the diagnosis, therapeutic options, and criteria for invasive intervention in patients with renal AML. Computerized tomography is the standard diagnostic method for renal AML, while definitive diagnosis is made by histopathology. The management of choice in most cases is active surveillance (AS), with a clinical and imaging follow-up protocol. In high-risk cases, therapeutic management should be considered, with alternatives such as selective arterial embolization (SAE), nephron-sparing surgery (NSS), and mTOR inhibitors in selected patients. Renal AML in women of childbearing age, those with growth >0.25 cm/year, intralesional aneurysms >5 mm, and clinically significant symptoms may qualify for active treatment. Despite the limitations derived from the available evidence, it is possible to consider SAE, NSS, and the use of mTOR inhibitors as management alternatives for selected patients. Codon Publications 2022-01-21 /pmc/articles/PMC8792032/ /pubmed/35096516 http://dx.doi.org/10.15586/jkcvhl.v9i1.177 Text en Copyright: Álvarez-Restrepo JC, et al. https://creativecommons.org/licenses/by/4.0/This open access article is licensed under Creative Commons Attribution 4.0 International (CC BY 4.0). http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Narrative Review
Restrepo, Juan Camilo Álvarez
Millan, David Andres Castañeda
Sabogal, Carlos Andres Riveros
Bernal, Andres Felipe Puentes
Donoso, Wilfredo Donoso
New Trends and Evidence for the Management of Renal Angiomyolipoma: A Comprehensive Narrative Review of the Literature
title New Trends and Evidence for the Management of Renal Angiomyolipoma: A Comprehensive Narrative Review of the Literature
title_full New Trends and Evidence for the Management of Renal Angiomyolipoma: A Comprehensive Narrative Review of the Literature
title_fullStr New Trends and Evidence for the Management of Renal Angiomyolipoma: A Comprehensive Narrative Review of the Literature
title_full_unstemmed New Trends and Evidence for the Management of Renal Angiomyolipoma: A Comprehensive Narrative Review of the Literature
title_short New Trends and Evidence for the Management of Renal Angiomyolipoma: A Comprehensive Narrative Review of the Literature
title_sort new trends and evidence for the management of renal angiomyolipoma: a comprehensive narrative review of the literature
topic Narrative Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792032/
https://www.ncbi.nlm.nih.gov/pubmed/35096516
http://dx.doi.org/10.15586/jkcvhl.v9i1.177
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