Differential roles for DNAJ isoforms in HTT-polyQ and FUS aggregation modulation revealed by chaperone screens

Protein aggregation is a hallmark of neurodegeneration. Here, we find that Huntington’s disease-related HTT-polyQ aggregation induces a cellular proteotoxic stress response, while ALS-related mutant FUS (mutFUS) aggregation leads to deteriorated proteostasis. Further exploring chaperone function as...

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Detalles Bibliográficos
Autores principales: Rozales, Kinneret, Younis, Amal, Saida, Naseeb, Meller, Anatoly, Goldman, Hodaya, Kellerman, Lior, Heinrich, Ronit, Berlin, Shai, Shalgi, Reut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792056/
https://www.ncbi.nlm.nih.gov/pubmed/35082301
http://dx.doi.org/10.1038/s41467-022-27982-w

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