Human induced pluripotent stem cells display a similar mutation burden as embryonic pluripotent cells in vivo

Induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine, but genetic instability is a major concern. Embryonic pluripotent cells also accumulate mutations during early development, but how this relates to the mutation burden in iPSCs remains unknown. Here, we directly com...

Descripción completa

Detalles Bibliográficos
Autores principales: Hasaart, Karlijn A.L., Manders, Freek, Ubels, Joske, Verheul, Mark, van Roosmalen, Markus J., Groenen, Niels M., Oka, Rurika, Kuijk, Ewart, Lopes, Susana M. Chuva de Sousa, Boxtel, Ruben van
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792070/
https://www.ncbi.nlm.nih.gov/pubmed/35118356
http://dx.doi.org/10.1016/j.isci.2022.103736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792070/
https://www.ncbi.nlm.nih.gov/pubmed/35118356
http://dx.doi.org/10.1016/j.isci.2022.103736

Ejemplares similares