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Human induced pluripotent stem cells display a similar mutation burden as embryonic pluripotent cells in vivo

Induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine, but genetic instability is a major concern. Embryonic pluripotent cells also accumulate mutations during early development, but how this relates to the mutation burden in iPSCs remains unknown. Here, we directly com...

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Detalles Bibliográficos
Autores principales:	Hasaart, Karlijn A.L., Manders, Freek, Ubels, Joske, Verheul, Mark, van Roosmalen, Markus J., Groenen, Niels M., Oka, Rurika, Kuijk, Ewart, Lopes, Susana M. Chuva de Sousa, Boxtel, Ruben van
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792070/ https://www.ncbi.nlm.nih.gov/pubmed/35118356 http://dx.doi.org/10.1016/j.isci.2022.103736

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