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Mechanosensitive channel Piezo1 induces cell apoptosis in pancreatic cancer by ultrasound with microbubbles
Ultrasound (US), as a safe and non-invasive tool, has drawn researchers' attention to treat pancreatic ductal adenocarcinoma (PDAC). Piezo1, a mechanosensitive channel, can be activated by various mechanical stimuli. In this study, we tested the expression of Piezo1 in PDAC cell lines and tissu...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792083/ https://www.ncbi.nlm.nih.gov/pubmed/35118354 http://dx.doi.org/10.1016/j.isci.2022.103733 |
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author | Song, Yue Chen, Jifan Zhang, Cong Xin, Lei Li, Qunying Liu, Yajing Zhang, Chao Li, Shiyan Huang, Pintong |
author_facet | Song, Yue Chen, Jifan Zhang, Cong Xin, Lei Li, Qunying Liu, Yajing Zhang, Chao Li, Shiyan Huang, Pintong |
author_sort | Song, Yue |
collection | PubMed |
description | Ultrasound (US), as a safe and non-invasive tool, has drawn researchers' attention to treat pancreatic ductal adenocarcinoma (PDAC). Piezo1, a mechanosensitive channel, can be activated by various mechanical stimuli. In this study, we tested the expression of Piezo1 in PDAC cell lines and tissues, and cell apoptosis in vitro and in vivo with siRNA, a lentivirus system, and a subcutaneous xenograft tumor-bearing model under the condition of US with microbubbles (MBs). We found that Piezo1 was highly expressed in PDAC cells; it was activated by US with MBs and was closely related to the apoptosis of PDAC cell lines and tumors. This study highlighted the idea of utilizing the high expression of Piezo1 in PDAC and US with MBs to provide a non-invasive strategy for the treatment of PDAC from the aspect of mechanotransduction. |
format | Online Article Text |
id | pubmed-8792083 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-87920832022-02-02 Mechanosensitive channel Piezo1 induces cell apoptosis in pancreatic cancer by ultrasound with microbubbles Song, Yue Chen, Jifan Zhang, Cong Xin, Lei Li, Qunying Liu, Yajing Zhang, Chao Li, Shiyan Huang, Pintong iScience Article Ultrasound (US), as a safe and non-invasive tool, has drawn researchers' attention to treat pancreatic ductal adenocarcinoma (PDAC). Piezo1, a mechanosensitive channel, can be activated by various mechanical stimuli. In this study, we tested the expression of Piezo1 in PDAC cell lines and tissues, and cell apoptosis in vitro and in vivo with siRNA, a lentivirus system, and a subcutaneous xenograft tumor-bearing model under the condition of US with microbubbles (MBs). We found that Piezo1 was highly expressed in PDAC cells; it was activated by US with MBs and was closely related to the apoptosis of PDAC cell lines and tumors. This study highlighted the idea of utilizing the high expression of Piezo1 in PDAC and US with MBs to provide a non-invasive strategy for the treatment of PDAC from the aspect of mechanotransduction. Elsevier 2022-01-07 /pmc/articles/PMC8792083/ /pubmed/35118354 http://dx.doi.org/10.1016/j.isci.2022.103733 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Song, Yue Chen, Jifan Zhang, Cong Xin, Lei Li, Qunying Liu, Yajing Zhang, Chao Li, Shiyan Huang, Pintong Mechanosensitive channel Piezo1 induces cell apoptosis in pancreatic cancer by ultrasound with microbubbles |
title | Mechanosensitive channel Piezo1 induces cell apoptosis in pancreatic cancer by ultrasound with microbubbles |
title_full | Mechanosensitive channel Piezo1 induces cell apoptosis in pancreatic cancer by ultrasound with microbubbles |
title_fullStr | Mechanosensitive channel Piezo1 induces cell apoptosis in pancreatic cancer by ultrasound with microbubbles |
title_full_unstemmed | Mechanosensitive channel Piezo1 induces cell apoptosis in pancreatic cancer by ultrasound with microbubbles |
title_short | Mechanosensitive channel Piezo1 induces cell apoptosis in pancreatic cancer by ultrasound with microbubbles |
title_sort | mechanosensitive channel piezo1 induces cell apoptosis in pancreatic cancer by ultrasound with microbubbles |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792083/ https://www.ncbi.nlm.nih.gov/pubmed/35118354 http://dx.doi.org/10.1016/j.isci.2022.103733 |
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