Anti-CAIX BBζ CAR4/8 T cells exhibit superior efficacy in a ccRCC mouse model

Improving CAR-T cell therapy for solid tumors requires a better understanding of CAR design and cellular composition. Here, we compared second-generation (BBζ and 28ζ) with third-generation (28BBζ) carbonic anhydrase IX (CAIX)-targeted CAR constructs and investigated the antitumor effect of CAR-T ce...

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Detalles Bibliográficos
Autores principales: Wang, Yufei, Buck, Alicia, Grimaud, Marion, Culhane, Aedin C., Kodangattil, Sreekumar, Razimbaud, Cecile, Bonal, Dennis M., Nguyen, Quang-De, Zhu, Zhu, Wei, Kevin, O'Donnell, Madison L., Huang, Ying, Signoretti, Sabina, Choueiri, Toni K., Freeman, Gordon J., Zhu, Quan, Marasco, Wayne A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792103/
https://www.ncbi.nlm.nih.gov/pubmed/35118195
http://dx.doi.org/10.1016/j.omto.2021.12.019

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