Hypothyroidism as an immune-related adverse event caused by atezolizumab in a patient with muscle spasms: a case report

A 60-year-old man with a history of 4 cycles of atezolizumab treatment for non-small cell lung cancer presented to our hospital with a chief complaint of proximal muscle-dominant spasms. Blood tests showed elevated creatine phosphokinase (CPK) of 8450 U/L and hypothyroidism. There was little improve...

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Detalles Bibliográficos
Autores principales: Kawataki, Masanori, Nakanishi, Yosuke, Yokoyama, Toshihide, Ishida, Tadashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792264/
https://www.ncbi.nlm.nih.gov/pubmed/35116222
http://dx.doi.org/10.1016/j.rmcr.2022.101585
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author Kawataki, Masanori
Nakanishi, Yosuke
Yokoyama, Toshihide
Ishida, Tadashi
author_facet Kawataki, Masanori
Nakanishi, Yosuke
Yokoyama, Toshihide
Ishida, Tadashi
author_sort Kawataki, Masanori
collection PubMed
description A 60-year-old man with a history of 4 cycles of atezolizumab treatment for non-small cell lung cancer presented to our hospital with a chief complaint of proximal muscle-dominant spasms. Blood tests showed elevated creatine phosphokinase (CPK) of 8450 U/L and hypothyroidism. There was little improvement even after stopping levetiracetam and pregabalin, and no subspinous physical findings of myositis. After levothyroxine was started for hypothyroidism, his muscle cramps and serum CPK level improved. Hypothyroidism as an immune-related adverse event can cause muscle spasms and is important in the differential diagnosis of muscle spasms in patients treated with immune checkpoint inhibitors.
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spelling pubmed-87922642022-02-02 Hypothyroidism as an immune-related adverse event caused by atezolizumab in a patient with muscle spasms: a case report Kawataki, Masanori Nakanishi, Yosuke Yokoyama, Toshihide Ishida, Tadashi Respir Med Case Rep Case Report A 60-year-old man with a history of 4 cycles of atezolizumab treatment for non-small cell lung cancer presented to our hospital with a chief complaint of proximal muscle-dominant spasms. Blood tests showed elevated creatine phosphokinase (CPK) of 8450 U/L and hypothyroidism. There was little improvement even after stopping levetiracetam and pregabalin, and no subspinous physical findings of myositis. After levothyroxine was started for hypothyroidism, his muscle cramps and serum CPK level improved. Hypothyroidism as an immune-related adverse event can cause muscle spasms and is important in the differential diagnosis of muscle spasms in patients treated with immune checkpoint inhibitors. Elsevier 2022-01-20 /pmc/articles/PMC8792264/ /pubmed/35116222 http://dx.doi.org/10.1016/j.rmcr.2022.101585 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kawataki, Masanori
Nakanishi, Yosuke
Yokoyama, Toshihide
Ishida, Tadashi
Hypothyroidism as an immune-related adverse event caused by atezolizumab in a patient with muscle spasms: a case report
title Hypothyroidism as an immune-related adverse event caused by atezolizumab in a patient with muscle spasms: a case report
title_full Hypothyroidism as an immune-related adverse event caused by atezolizumab in a patient with muscle spasms: a case report
title_fullStr Hypothyroidism as an immune-related adverse event caused by atezolizumab in a patient with muscle spasms: a case report
title_full_unstemmed Hypothyroidism as an immune-related adverse event caused by atezolizumab in a patient with muscle spasms: a case report
title_short Hypothyroidism as an immune-related adverse event caused by atezolizumab in a patient with muscle spasms: a case report
title_sort hypothyroidism as an immune-related adverse event caused by atezolizumab in a patient with muscle spasms: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8792264/
https://www.ncbi.nlm.nih.gov/pubmed/35116222
http://dx.doi.org/10.1016/j.rmcr.2022.101585
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